Clusterin在卵巢癌中的研究进展

丛生蛋白（Clusterin，CLU）是一种广泛存在于各种组织中并表达的糖蛋白，参与多种生理病理过程。丛生蛋白（CLU）在肿瘤发生发展过程中起重要作用。在卵巢癌的研究中，CLU也被认为与其发生发展及预后有着密切的联系，CLU的高表达可能与卵巢癌的预后不良有关。CLU也被认为与增加卵巢癌对紫杉醇的耐药有关，因此针对Clus-terin基因的分子靶向治疗可以增加对紫杉醇类抗癌药物的敏感性。本文就CLU在卵巢癌中的研究进展作一综述。

Progression of clusterin in ovarian cancer

Clusterin （CLU） is an enigmatic glycoprotein with ubiquitous tissue distribution, and involved in many biological processes and pathological states. Clusterin plays an important role in the process of cancer. In ovarian cancer, GLU was reported to correlate with the tumorigenesis and progression. The high expression of GLU may be related to the poor prognosis of ovarian cancer in survival analysis. CLU is also thought to associated with drug resistance of paeli- taxel in ovarian cancer, thus molecular targeted therapy for Clusterin gene can increase the sensitivity of paclitaxel.