Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese |
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| Institution: | 1. Institute of Applied Problems of Physics, NAS of Armenia, 25 Nersessyan Str., 0014, Yerevan, Armenia;2. School of Chemical Sciences, Goa University, Goa 403206, India;1. School of the Earth Sciences and Resources, China University of Geosciences, Beijing, China;2. Dinosaur Trackers Research Group, University of Colorado, Denver, CO, USA;3. Regional Geological Survey Team, Sichuan Bureau of Geological Exploration and Development of Mineral Resources, Chengdu 610213, China;4. School of Earth Sciences, University of Bristol, Bristol BS8 1RJ, UK;5. Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China;6. Saurierwelt Paläontologisches Museum, Neumarkt, Germany;7. Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada;8. Department of Earth Science Education, Korea National University of Education, Cheongwon, Chungbuk 363-791, South Korea;9. Zigong Dinosaur Museum, Zigong, Sichuan, China;10. Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection, Ministry of Education, Guilin 541004, China;1. Division of Cardiology, Stavanger University Hospital, 4068 Stavanger, Norway;2. Department of Medicine, Stavanger University Hospital, 4068 Stavanger, Norway;3. Department of Clinical Science, University of Bergen, 5020 Bergen, Norway;4. Sigma Statistical Services, KY16 0BJ Balmullo, UK;5. Sanford School of Medicine, University of South Dakota, OmegaQuant Analytics, LLC, Sioux Falls, SD, United States;1. Institute of Epigenetics and Epigenomics, Yangzhou University, 48 Wenhui East Road, Yangzhou, Jiangsu 225009, China;2. College of Animal Science and Technology, Yangzhou University, 48 Wenhui East Road, Yangzhou, Jiangsu 225009, China;3. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA;4. Ralph H Johnson Veteran''s Affairs Medical Center, 109 Bee St, 29403, Charleston, SC, USA;5. Union Hospital of Cecil County, 106 Bow St, Elkton, MD 21921, USA |
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| Abstract: | ObjectiveTo investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA + DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake.MethodWe cross-sectionally studied 3383 Japanese local government workers aged 35–66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA + DHA intake as the reference were calculated by logistic regression analysis.ResultsMean age, body mass index (BMI), and dietary ALA, and median of dietary EPA + DHA were 47.9 years, 22.9 kg/m2, and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1 = 0.74, P for trend = 0.01) and the association was observed only in subjects with a BMI of < 25 kg/m2 (P for interaction = 0.033). However EPA + DHA showed no such associations consistently.ConclusionHigher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women. |
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