Chlorpromazine specifically prevents the wheel-induced feeding suppression in rats |
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| Institution: | 1. Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Department of Chemistry, Richardson College of the Environmental Science Complex, The University of Winnipeg, Winnipeg, Canada;1. Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussel, Belgium;2. Faculté de Psychologie et des Sciences de l''Education, Université de Mons, Place du Parc 20, 7000 Mons, Belgium;3. UPC KU Leuven - Campus Kortenberg, Department of Neurosciences, KU Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium;4. National MS Center Melsbroek, Vanheylenstraat 16, 1820 Melsbroek, Belgium;1. Department of Physiology, Faculty of Medicine, University of Szeged, Dóm tér 10., H-6720 Szeged, Hungary;2. Department of Image Processing and Computer Graphics, Institute of Informatics, Faculty of Science and Informatics, University of Szeged, Árpád tér 2., H-6720 Szeged, Hungary;1. Department of Neurology, University of Würzburg, Würzburg, Germany;2. Department of Neurology, Caritas Hospital, Bad Mergentheim, Germany |
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| Abstract: | In rats, limited daytime wheel access suppresses feeding over the subsequent night Lattanzio SB, Eikelboom R. Wheel access duration in rats: I. effects on feeding and running. Behav Neurosci 2003; 117:496–504.]. This phenomenon is known as the wheel-induced feeding suppression (WIFS). The classic antipsychotic, chlorpromazine, can minimize the severity of the related activity anorexia procedure, but is thought to act through a suppression of running Routtenberg A. “Self-starvation” of rats living in activity wheels: adaptation effects. J Comp Physiol Psychol 1968; 66:234–8.]. We tested the effects of chlorpromazine (2 mg/kg IP) on the acute WIFS in 40 adult male rats by administering the drug before or after 3 h of daytime wheel access and measuring food consumption over the subsequent 24 h. Control groups received saline injections or were exposed to locked wheels. While chlorpromazine did not attenuate feeding or change wheel running alone, it blocked their interaction, the acute WIFS. This procedure might be useful in screening drugs for anorexia nervosa where exercise is often elevated and feeding is suppressed. |
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