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Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90 |
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| Authors: | Ryningen Anita Ersvaer Elisabeth Øyan Anne Margrete Kalland Karl-Henning Vintermyr Olav Karsten Gjertsen Bjørn Tore Bruserud Øystein |
| Affiliation: | aDivision for Hematology, Department of Medicine, Haukeland University Hospital and The University of Bergen, Bergen, Norway bSection for microbiology and immunology, Haukeland University Hospital and The University of Bergen, Bergen, Norway cDepartment of Pathology, The Gade Institute, Haukeland University Hospital and The University of Bergen, Bergen, Norway |
| Abstract: | Spontaneous in vitro apoptosis reflects a true biological heterogeneity between patients which has to be considered when in vitro models are used to study regulation of apoptosis in native human AML cells. Even though the balance between pro- and anti-apoptotic signaling seems to have a prognostic impact in AML, the possible clinical relevance of spontaneous apoptosis remains to be clarified. High apoptosis/low viability was associated with low levels of heat shock proteins 70 and 90 as well as low Bcl-2:Bax ratio for patients heterogeneous with regard to morphology, membrane molecule expression, genetic abnormalities and response to therapy. |
| Keywords: | Acute myelogenous leukemia Spontaneous apoptosis Flow cytometry |
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