| VEGFR-3在食管鳞癌中的表达及与新生淋巴管形成的关系 |
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| 引用本文： | 马惠文,梁后杰.VEGFR-3在食管鳞癌中的表达及与新生淋巴管形成的关系[J].第三军医大学学报,2004,26(17):1580-1583. |
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| 作者姓名： | 马惠文 梁后杰 |
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| 作者单位： | 第三军医大学西南医院肿瘤科,重庆,400038;第三军医大学西南医院肿瘤科,重庆,400038 |
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| 摘 要： | 目的探讨VEGFR-3在食管鳞癌中的表达及其与新生淋巴管形成的关系.方法对73例食管鳞癌手术标本采用RT-PCR和免疫组化方法检测VEGFR-3的表达,采用免疫组化方法观察淋巴管生成,并探讨VEGFR-3与淋巴管形成的关系.结果VEGFR-3 mRNA与淋巴结转移密切相关,VEGFR-3阳性管腔计数也与淋巴结转移密切相关(P＜0.05).结论VEGFR-3与新生淋巴管的形成有相关性.
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| 关 键 词： | VEGF-C VEGFR-3 淋巴生成 |
| 文章编号： | 1000-5404(2004)17-1580-04 |
| 修稿时间： | 2004年3月19日 |
Relationship between expression of vascular endothelial growth factor receptor 3 and lymphangiogenesis in esophageal carcinoma |
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| MA Hui wen,LIANG Hou jie.Relationship between expression of vascular endothelial growth factor receptor 3 and lymphangiogenesis in esophageal carcinoma[J].Acta Academiae Medicinae Militaris Tertiae,2004,26(17):1580-1583. |
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| Authors: | MA Hui wen LIANG Hou jie |
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| Abstract: | Objective To investigate the relationship between the expression of vascular endothelial growth factor receptor 3 (VEGFR 3) and lymphangiogenesis in esophageal carcinoma. Methods VEGFR 3 expression in the esophageal carcinoma tissues from 73 cases was detected by RT PCR and immunobistochemical method. and the relationship between VEGFR 3 and lymphangiogenesis was analyzed. Results There was a statistically positive correlation between VEGFR 3 mRNA expression and lymph node metastasis in primary tumors ( P <0.05). The number of VEGFR 3 positive lymphatic vessels in the tumor was also closely related to the lymph node metastasis of esophageal carcinoma. Conclusion There is a close relationship between VEGFR 3 and lymphangiogenesis in esophageal carcinoma. |
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| Keywords: | VEGF-C VEGFR-3 |
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