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气相色谱法测定消糜栓中冰片(龙脑)的含量
引用本文:伊文敏,汪秀月.气相色谱法测定消糜栓中冰片(龙脑)的含量[J].安徽医药,2010,14(4):415-416.
作者姓名:伊文敏  汪秀月
作者单位:安徽省阜阳市肿瘤医院;安徽省阜阳市药品检验所,安徽,阜阳,236000
摘    要:目的建立气相色谱法测定消糜栓中冰片(以龙脑计)的含量。方法采用气相色谱法,色谱柱为聚乙二醇-20M毛细管柱30m×0.53mm×0.25μm,程序升温,起始温度90℃,每分钟升10℃,升至170℃后保持10分钟,分流比50:1,FID检测器;检测口温度为250℃。结果用气相色谱法测定消糜栓中冰片(以龙脑计)在0.127~0.762g·L^-1范围内呈良好的线性关系,线性方程为Y=0.7339—0.4077X,r=0.9998。平均回收率98.3%(n=9),RSD1.4%。结论本方法简便、准确、快速,可用于消糜栓的质量控制。

关 键 词:消糜栓  冰片  气相色谱法

Determination of borneol in xiaomi suppository by gas chromatography
YI Wen-min,WANG Xiu-yue.Determination of borneol in xiaomi suppository by gas chromatography[J].Anhui Medical and Pharmaceutical Journal,2010,14(4):415-416.
Authors:YI Wen-min  WANG Xiu-yue
Institution:1.Fuyang Cancer Hospital;2.Fuyang Institute for Drug Control;Fuyang 236000
Abstract:Aim To establish a gas chromatography(GC)method to determine the content of borneol in xiaomi suppository.Method A PEG-20M column was used(30 m × 0.53 mm × 0.25 μm).Column temperature was raised by programming,with an original temperature at 90℃,then raised to 200℃ at the rate of 10℃·min-1 and kept for 10 minutes.Distributary ratio was 50∶1 and FID temperature was 250℃.Results The linear range of borneol was from 0.127 to 0.762 g·L-1.The average recovery was 98.3﹪(n=9),and RSD was 1.4﹪.Conclusion The method is simple,accurate and quick,which can be used to control the quality of xiaomi suppository.
Keywords:xiaomi suppository  borneol  GC  
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