心肌声学造影视频法与射频法定量分析方法比较研究

目的　比较超声组织定征视频法与射频法在心肌声学造影定量分析中的应用价值。方法　 8只开胸犬 ,经静脉滴注全氟显进行谐波触发显像 ,分别采用DFY型超声图像定量分析诊断仪和声学密度定量 (AD)技术获得心肌声学造影感兴趣区回声强度 (EI)和背向散射积分 (IBS)值 ,并绘制时间 强度曲线 (TIC)。结果　心肌缺血后 ,峰值回声强度 (PEI)、峰值背向散射积分值 (PIBS)降低 ,P值均 <0 .0 5 ;而达PEI及PIBS所需时间 (PT)延长 ,P值均 <0 .0 1。冠脉闭塞后 ,PEI及PIBS显著降低 ,P值均 <0 .0 1。结论　超声组织定征视频法与射频法均能用于心肌声学造影的定量分析 ,两者均能区分缺血与梗塞心肌。

Quantitative Assessment of Myocardial Blood Flow with Contrast Echocardiography: Comparative Study between Video Frequency Method and Radio Frequency Method

Objective To compare the value of two ultrasonic tissue characterization (UTC) methods (video frequency method and radio frequency method) in quantitative myocardial contrast echocardiography. Methods Eight open chest canine models were established. Intermittent harmonic imaging was performed with continuous intravenous injection of a perflurocarbon contrast agent while normally perfused, coronary stenosis or occlusion. The parameters of time intensity curve (TIC) were obtained with DFY quantitative analysis system and acoustic densitometry technique, respectively. Results Among the parameters derived from TIC, peak echo intensity (PEI) and peak integrated backscatter(PIBS) decreased while the coronary artery was stenosis ( P <0.05) or occlusion ( P <0.01). Time to PEI and PIBS increased while the coronary artery was occlusion. Conclusion Both the methods of UTC can differentiate ischemia and infarcted myocardium from normal, and can be used in quantitative myocardial contrast echocardiography.