INCREASED APOTRANSCOBALAMIN II LEVELS IN RHEUMATOID ARTHRITIS |
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| Authors: | ARNALICH, F. ZAMORANO, A. F. BENITO-URBINA, S. GIJON-BANOS, J. MIGUEL, E. DE PENA, J. M. VAZQUEZ, J. J. |
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| Affiliation: | *Department of Medicine, La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain
!["{dagger}"]("/math/dagger.gif") Division of Haematology, La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain
!["{ddagger}"]("/math/Dagger.gif") Division of Rheumatology Unit, La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain
La Paz Hospital, Autonomous Faculty of Medicine Madrid, Spain |
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| Abstract: | The distribution of endogenous cobalamin among serum cobalamin-bindingproteins was studied in 30 patients with active rheumatoid arthritis(RA) and 27 in clinical remission The mean total serum cobalamin concentration (holo-transcobalaminI and II) was similar in both groups of patients, whereas meanapotranscobalamin II was significantly increased in patientswith active RA. The clinical significance of this finding isnot yet established but it might be a useful parameter for theevaluation of disease activity in RA KEY WORDS: Rheumatoid arthritis, Serum cobalamin-binding proteins, Apotranscobalamin II, Vitamin B12 binding proteins |
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