美心力与硝酸甘油联用治疗充血性心力衰竭的临床观察

目的 探讨美心力对充血性心力衰竭（ＣＨＦ）患者的治疗效果。方法 选择ＣＨＦ心功能Ⅲ～Ⅳ级住院患者６０例。随机分为治疗组３０例。采用美心力和硝酸甘油联用；对照组３０例，单用硝酸甘油。比较治疗前后两组的临床症状、体征和心功能分级、心功能指标。并观察疗效和记录有无副作用。结果 治疗组临床总有效率８３．３％。对照组总有效率７６．６％（Ｐ〈０．０５）。心功能测定，治疗组治疗前后比较各项指标改善均有显著性差异（Ｐ〈０．０１），对照组收缩功能改善有显著性差异（Ｐ〈０．０１）。舒张功能无改善（Ｐ〉０．０５）。治疗组与对照组比较。收缩功能改善无差异（Ｐ〉０．０５）。而舒张改善有显著差异（Ｐ〈０．０１）。治疗组在用药过程中未见毒副作用。结论 美心力是治疗ＣＨＦ患者安全有效的药物，可作为ＣＨＦ综合治疗药物之一用于临床。

Clinical investigation of the effects of cAMP and nitroglycerin in severe congestive heart failure

Objectives To evaluate the therapeutic effect of cAMP on patients with congestive heart failure(CHF).Methods 60 patients with CHF ( NYHA class Ⅲ～Ⅳ) were treated in hospital, and were divided into two groups, cAMP group(n = 30) were treated with cAMP and nitroghycerin, control group (n= 30)were treated only with nitroglycerin. Before and after the treatment, clinical symptoms, singns, cardiac functional classes and inotropic indices of both groups were investigated, the side - effects were also observed and recorded. Results Total effective rate of the cAMP group was 83.3 % and the control group was 76.6% (P＜0.05) .After the treatment,cardiac function increased temmkabaly compared with before in the cAMP group( P < 0.01 ) ,the systolic function increased remarkabaly in the control group( P＜0.01 ) ,the diastolic function were not changed( P＞0.05) .After treament, compared with the conuol group,the systolic function not increased remarkabaly(P＞0.05) ,the diastolic function increased remarkabaly in the cAMP group( P＜0.01) .There were no significant side - effects observed in the cAMP group. Conclusions cAMP was a safe, effective drug for the patients with CHF, could be one of the effective drug to treat CHF.