米力农治疗难治性心力衰竭56例

目的：评价米力农治疗难治性心力衰竭（RHF）的疗效。方法：对56例患者给予米力农5mg加入5％葡萄糖或0．9％氯化钠注射液250mL，静脉滴注，qd,7d为1个疗程，观察患者治疗前后症状、体征、血压、心率及心功能指标。结果：①米力农治疗难治性心力衰竭总有效率85．75；②治疗后左室身血分数（LVEF）、左室短轴缩短率（FS）均明显增加（P＜0．01），舒张早期最大充盈速度（E）与舒张晚期最大充盈速度（A）比值（E／A）明显增加（P＜0．05）。结论：米力农治疗RHF有较好的疗效，不仅能改善患者患者心脏收缩功能，而且能改善舒张功能。

Therapeutic Effect of milrinone in Treatment of Refractory Heart Failure Patients

Objective:To evaluate the effect of milrinone in treating refractory heart failure. Methods:5mg of milrinone in 250ml of 5% Glucose or 0.9% NaCl Solution were given daily by intravenous drip to 56 cases of refractory heart failure for a period of consecutive 7 days. The symptoms and signs were observed before and after the treatment, heart rate, blood pressure and heart function examined by Doppler echocardiography. Results:a. The total effective rate was 85.7%. b. The left ventricular ejection fraction (LVEF) and fraction shortening (FS) were increased significantly ( P <0.01) after treatment. The rate of filling velocity in early diastole (E) over that in late diastole (A) was increased significantly ( P <0.05). Conclusion:Milrinone has good effect for treating refractory heart failure. It improves not only the cardiac systolic function but also the diastolic function.