| 脑梗死患者纤溶酶原激活物抑制剂-1 4G/5G基因多态性的研究 |
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| 引用本文： | 胡均培,严为宏,邹丽芳,窦红菊,庄衍,程毅敏.脑梗死患者纤溶酶原激活物抑制剂-1 4G/5G基因多态性的研究[J].血栓与止血学,2005,11(3):112-113. |
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| 作者姓名： | 胡均培 严为宏 邹丽芳 窦红菊 庄衍 程毅敏 |
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| 作者单位： | 上海第二医科大学附属第九人民医院血液科,上海,200011 |
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| 摘 要： | 目的研究纤溶酶原激活物抑制剂-1(PAI-1)基因多态性对脑梗死发病的影响.方法对52例脑梗死患者和31名正常对照者进行PAI-1
4G/5G基因多态性的检测,同时进行血浆PAI-1活性测定.结果通过基因多态性的检测,脑梗死患者4G/5G基因型的比例明显高于正常对照组(P=0.021).在PAI-1活性测定中,脑梗死组高于对照组(P＜0.01).脑梗死和正常对照组中4G/5G基因者的PAI-1活性均大于4G/5G基因型个体(P＜0.01或P＜0.05).结论PAI-1及4G/5G基因多态性可能在脑梗死的发病中起重要作用.
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| 关 键 词： | 脑梗死 纤溶酶原激活物抑制剂-1 基因多态性 |
| 文章编号： | 1009-6213(2005)03-112-02 |
| 修稿时间： | 2004年10月20 |
Plasminogen Activator Inhibitor-1 (PAI-1)4G/5G Polymorphism in Subjects with Cerebral Infarction |
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| Hu Jun-pei,YAN Wei-hong,ZOU Li-fang,DOU Hong-ju,ZHUANG Yan,CHENG Yi-min.Plasminogen Activator Inhibitor-1 (PAI-1)4G/5G Polymorphism in Subjects with Cerebral Infarction[J].Chinese Journal of Thrombosis and Hemostasis,2005,11(3):112-113. |
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| Authors: | Hu Jun-pei YAN Wei-hong ZOU Li-fang DOU Hong-ju ZHUANG Yan CHENG Yi-min |
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| Abstract: | Objective To study the effect of PAI-1 4G/5G polymorphism on cerebral infarction (CI), Methods PAI-1 4G/5G polymorphism and PAI-1 activity were measured in 52 CI patients and 31 controls. Results The distribution of PAI-1 4G/4G genotypes in the patients was more than that in controls (P= 0. 021). PAI-1 activity in patients was significantly higher than in controls(P <0. 01). PAI-1 activity in both patients and controls with 4G/4G genotype was highev than that in those with 4G/5G genotype. Conclusion PAI-1 as well as PAI-1 4G/5G polymorphim might play an important role in pathogenesis of CI. |
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| Keywords: | Cerebral infarction Plasminogen activator inhibitor-1 Gene polymorphism |
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