Intracardiac thrombus may develop as a consequence of multiple underlying cardiac disorders. Other systemic disorders may predispose formation of thrombus within the heart, or the heart may be the site of emboli in transitthrombus originating elsewhere and traveling through the heart to the pulmonary or arterial circulation. Part V of this five-port series on intracardiac thrombus will focus on “migrating thrombi,” miscellaneous systemic conditions associated with intracardiac thrombi, and echocardiographic detection of intracardiac thrombus.