Autism and genetics: Clinical approach and association study with two markers of HRAS gene |
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| Authors: | Josiane H rault,Elisabeth Petit,Joë lle Martineau,Anne Perrot,Pascal Lenoir,Catherine Cherpi,Catherine Barth l my,Dominique Sauvage,Jacques Mallet,Jean Pierre Mü h,Gilbert Lelord |
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| Affiliation: | Josiane Hérault,Elisabeth Petit,Joëlle Martineau,Anne Perrot,Pascal Lenoir,Catherine Cherpi,Catherine Barthélémy,Dominique Sauvage,Jacques Mallet,Jean Pierre Müh,Gilbert Lelord |
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| Abstract: | Twin studies and familial aggregation studies indicate that genetic factors could play a role in infantile autism. In an earlier study, we identified a possible positive association between autism and a c-Harvey-ras (HRAS) oncogene marker at the 3′ end of the coding region. In an attempt to confirm this finding, we studied a larger population, well-characterized clinically and genetically. We report a positive association between autism and two HRAS markers, the 3′ marker used in the initial study and an additional marker in exon 1. © 1995 Wiley-Liss, Inc. |
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| Keywords: | child psychiatry infantile autism HRAS gene clinical evaluation polymorphism |
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