潘妥拉唑及奥美拉唑对健康人胃内pH的影响

探讨潘妥拉唑及奥美拉唑对健康人２４ｈ胃内ＰＨ的影响。方法：２８例健康志愿者随机分为３组,其中ＰＡＮ组１０例,ＯＭＥ组８例,分别静脉滴注ＰＡＮ８０ｍｇ,ＯＭＥ８０ｍｇ,１次／ｄ,连续２ｄ,第２天给药后进行胃内ＰＨ２４ｈ监测;对照组１０例,直接进行胃内ＰＨ２４ｈ监测。结果：ＰＡＮ及ＯＭＥ均能明显提高２４ｈ胃内ＰＨ平均值,ＰＨ〉４总时间百分比及２４ｈ胃内ＰＨ变化,工线下面积（Ｐ〈０．０１）;用药后２４ｈ

Effect of pantoprazol and omeprazol on 24 h intragastric pH in healthy human subjects

Objective: To investigate the effects of pantoprazol and omeprazol on 24 h intragastric pH in healthy human subjects. Methods: Twenty eight healthy volunteers were randomized into 3 groups. Ten subjects in pantoprazol group received 80 mg pantoprazol intravenously for 2 days and received 24 h intragastric pH monitoring in the second day. Eight subjects in omeprazol group received 80 mg omeprazol intravenously for 2 days and had 24 h intragastric pH monitoring in the same way. The other 10 subjects were in control group and 24 h intragastric pH monitoring were carried out directly. Results: Both pantoprazol and omeprazol could greatly increase the 24 h intragastric mean pH, the total percentage time of intragastric pH>4 and the area under the curve of intragastric pH ( P <0.01). Every hour during 24 h after drug administration, the intragastric pH was also greatly increased ( P <0.01). Compared with omeprazol, pantoprazol had more significant effect on increasing the 24 h mean pH ( P <0.05) and the area under the curve of intragastric pH ( P <0.01). There were 13 hours in one day after drug administration, the intragastric pH were even higher in pantoprazol group than in omeprazol group ( P <0.05). Conclusion: Both pantoprazol and omeprazol have great inhibitory effect on gastric acid secretion, but the effect of the former is stronger.