| 盐酸阿洛司琼片剂的研制 |
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| 引用本文： | 郭德琴,阿基业. 盐酸阿洛司琼片剂的研制[J]. 药学与临床研究, 2001, 9(4): 12-14 |
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| 作者姓名： | 郭德琴 阿基业 |
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| 作者单位： | 1. 江浦县人民医院,南京,211800
2. 中国药科大学,南京,210009 |
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| 摘 要： | 研制盐酸阿洛司琼片剂,建立了紫外分光光度法测定片剂的含量.在0.1 mol/L盐酸溶液中测定波长为295 nm,标准曲线A=0.0279C-0.0012,相关系数r=0.9999.加样回收率分别为99.01%、99.48%、100.63%,RSD均小于1%.三批片剂的含量分别为99.32%、100.04%、99.70%,含量均匀度分别为6.61、6.97、5.05,日间和日内误差分别为0.88%、0.63%.三批片剂30min的溶出度高于90%.
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| 关 键 词： | 盐酸阿洛司琼 溶出度 片剂 制备 |
| 修稿时间： | 2001-06-20 |
Preparation and study of Alosetron hydrochloride tablets |
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| Guo Deqing A JiyeJiangpu People''''s Hospital. Preparation and study of Alosetron hydrochloride tablets[J]. Pharmacertical and Clinical Research, 2001, 9(4): 12-14 |
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| Authors: | Guo Deqing A JiyeJiangpu People''''s Hospital |
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| Affiliation: | Guo Deqing A JiyeJiangpu People's Hospital (Nanjing 211800) China Pharmaceutical University (Nanjing 210009) |
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| Abstract: | Alosetron hydrochloride tablets were prepared and studied. The content of tablets was determined by method of UV spectrum. The wavelength was defined at 295 nm in 0. 1 mol/L hydrochloride solution. The equation of standard curve was expressed asA = 0. 0279C-0. 0012, r = 0. 9999. The contents of three batches were 99. 32%, 100. 04%,99. 70%, respectively. The evenness was 6. 61, 6. 97, 5. 05. Recovery was 99. 01 % . 99. 48% , 100. 63% . respectively. RSD was less than 1 %. The SD for within-day and between-days is 0. 88% , 0. 63%. Average dissolution rates of three batches were greater than 90% at 30 minutes. |
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| Keywords: | Alosetron hydrochloride: Dissolution rate Tablet Preparation |
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