| 辐照猪皮与重组人表皮生长因子凝胶治疗小面积Ⅱ度烧伤的临床观察 |
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| 引用本文： | 王震,葛良鹏,荣新洲,魏泓,刘立柱,杨荣华,张涛.辐照猪皮与重组人表皮生长因子凝胶治疗小面积Ⅱ度烧伤的临床观察[J].第三军医大学学报,2010,32(1). |
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| 作者姓名： | 王震 葛良鹏 荣新洲 魏泓 刘立柱 杨荣华 张涛 |
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| 作者单位： | 1. 广州医学院附属广州市第一人民医院烧伤科,广州,510180
2. 第三军医大学基础医学部实验动物学教研室,重庆,400038 |
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| 摘 要： | 目的观察辐照猪皮与重组人表皮生长因子(recombinant human epidermal growth factor,rhEGF)凝胶用于治疗Ⅱ度烧伤的临床疗效。方法选择135例Ⅱ度烧伤患者,分成3组,分别是辐照猪皮组、rhEGF凝胶组和对照组(碘伏油纱组),观察创面愈合时间、患者疼痛度、换药工作量、色素沉着度、愈合后效果以及1年后随访效果。结果不同治疗方式的愈合时间:对照组>rhEGF凝胶组>辐照猪皮组。辐照猪皮组和rhEGF凝胶组对Ⅱ度烧伤创面的治疗效果均优于对照组,平均愈合时间提前3～5 d,差异有统计学意义(P<0.01),且辐照猪皮组效果要略优于rhEGF凝胶组(P<0.05);rhEGF凝胶组和辐照猪皮组的患者疼痛度减轻及换药工作量相对对照组明显减少(P<0.01),且患者创面愈合效果良好、较少引起色素沉着,1年后部分患者随访证实远期愈合效果好,较少引起瘢痕增生。结论辐照猪皮和rhEGF治疗Ⅱ度烧伤效果确切、预后良好,临床上值得广泛使用。
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| 关 键 词： | 辐照猪皮 重组人表皮生长因子凝胶 碘伏 Ⅱ度烧伤 |
Irradiated pigskin graft dressing and recombinant human epidermal growth factor gel application in treatment of small-area partial-thickness burn:report of 135 cases |
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| Wang Zhen,Ge Liangpeng,Rong Xinzhou,Wei Hong,Liu Lizhu,Yang Ronghan,Zhang Tao.Irradiated pigskin graft dressing and recombinant human epidermal growth factor gel application in treatment of small-area partial-thickness burn:report of 135 cases[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(1). |
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| Authors: | Wang Zhen Ge Liangpeng Rong Xinzhou Wei Hong Liu Lizhu Yang Ronghan Zhang Tao |
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| Institution: | 1Department of Burn Surgery;Guangzhou First People's Hospital;Guangzhou Medical College;Guangzhou;Guangdong Province;510180;2Department of Laboratory Animal Sciences;College of Basic Medical Sciences;Third Military Medical University;Chongqing;400038;China |
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| Abstract: | Objective To investigate the therapeutic effect of the application of recombinant human epidermal growth factor(rhEGF) gel and the dressing of the irradiated pigskin graft in the treatment of small-area partial-thickness burn injury,and compare the outcomes with topically use of povidone iodine.Methods Totally 135 cases of patients with TBSA<10% partial-thickness burns admitted in our hospital from March 2007 to March 2008 were randomly divided into 3 groups: rhEGF gel groups(n=53),irradiated pigskin graft ... |
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| Keywords: | recombinant human epidermal growth factor gel irradiated pigskin graft povidone iodine partial-thickness burn |
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