山莨菪碱足三里穴位注射并口服脾可欣颗粒治疗婴幼儿轮状病毒性肠炎的研究

目的探讨山莨菪碱足三里穴位注射并口服脾可欣颗粒治疗婴幼儿轮状病毒性肠炎的疗效及安全性。方法将720例婴幼儿轮状病毒性肠炎患儿随机分为A、B、C、D4组。A组（165例）：给予常规治疗;B组（170例）：在常规治疗的基础上给予口服脾可欣颗粒;C组（169例）：在常规治疗的基础上给予山莨菪碱足三里穴位注射;D组（216例）：在常规治疗的基础上给予山莨菪碱足三里穴位注射并口服脾可欣颗粒;比较4组患儿治疗3天后临床疗效及不良反应发生情况。结果总有效率C组和D组明显高于A组和B组（P〈0.01）,显效率、轮状病毒转阴率D组明显高于A组（P〈0.01）、B组（P〈0.01）和C组（P〈0.05）,病情复发率D组显著低于C组（P〈0.01）;4组均无明显不良反应发生。结论山莨菪碱足三里穴位注射并口服脾可欣颗粒治疗婴幼儿轮状病毒性肠炎安全、有效,值得在临床推广应用。

Study of effects of acupuncture in Zusanli with anisodamine Combined with PiKeXin electuary orally on infantile rotavirus Colitis

Objective To explore the curative effect and safety of acupuncture in zusanli with anisodamine combined with PiKeXin electuary orally on infantile rotavirus colitis. Methods 720 infantile patients suffering from rotavirus colitis were randomly divided into 4 groups. Group A (n=165) were given by routine treatment. Group B (n=170) and C (n=169) were given by PiKeXin electuary orally and acupuncture in zusanli with anisodamine on the basis of routine treatment. Group D (n=216) were given by acupuncture in zusanli with anisodamine combined with PiKeXin electuary orally on the basis of routine treatment. Clinical effects and adverse reactions were observed among 4 groups after 3 days treatment, Results The overall effective rates in group C and group D were significantly higher than that in group A and group B (P<0.01). The apparent effective rates and the negative rates of rotavirus in group D were significantly higher than that in group A(P<0.01), group B(P<0.01) and group C(P<0.05). The recurrent rates in group D was significantly lower than that in group C (P<0.01). There were less adverse reactions among 4 groups. Conclusions Acupuncture in zusanli with anisodamine combined with PiKeXin electuary orally on infantile rotavirus colitis is safe and effective,and it is worth spreading and application in clinic.