硫酸庆大霉素聚氰基丙烯酸正丁酯毫微球的体外释药动力学研究

考察了不同配方硫酸庆大霉素毫微球的体外释药动力学特征。分别用3种数学模型对释药数据进行拟合,结果表明,双指数函数模型能较好地描述硫酸庆大霉素从毫微球中的释药规律,据此计算了释药动力学参数。试验表明,毫微球的粒度、稳定剂的种类、制备工艺和载药量等对释药过程均有影响。

STUDIES ON IN VITRO RELEASE KINETICS OF GENTAMICIN SULFATE POL YBUTYLCYANOACRYLATE NANOPARTICLES

The in vitro release characteristics of gentamicin sulfate pulybutylcyanoacrylate nanoparticles were studled using a dialysis system comprising dialysis bag and receptor chamber. The whole apparatus was placed in a water bath shaker thermostated at 37℃,and shaken at 50 cpm. The concentration of gentamicin in the receptor chamber was periodically determined by first derivative spectrometry.The results showed that the in vitro release of gentamicin sulfate from polybutylcyanoacrylate nanoparticles is characteristically biphasic,with an initial fast release(the burst effect),followed by a much slower release. These release profiles can be well modelled using a biexponential function. The related parameters of release kinetics have been calculated according to the blexponential function,and some factors that may affect the release characteristics were studied.