阿魏酸钠部分减轻氢化泼尼松引起的小鼠肝脏毒性

氢化泼尼松(Pred)20mg·kg^-1可明显增高小鼠sGPT与sGST水平,增加肝匀浆MDA含量及肝微粒体与线粒体膜流动性。表明Pred致sGPT及sGST水平增高与肝脂质过氧化作用增强及膜流动性改变有关。经1g阿魏酸钠(SF)100mg·kg^-1使sGPT与sGST水平降低,肝脏MDA含量减少,但sGPT与MDA仍高于正常对照组水平。肝微粒体膜流动性恢复,线粒体膜流动性进一步增高。电镜观察亦见线粒体仍有损害,提示SF不能完全对抗Pred所致肝损害。

SODIUM FERULATE ALLEVIATES PREDNISOLONE INDUCED LIVER TOXICITY IN MICE

Prednisolone (Pred)20mg.kg^-1sc caused an increase in serum glutamic-pyruvic transaminase(sGPT) and serum glutathione S-transferase(sGST)activities and an elevation of MDA content in mouse liver homogenate. An increase of membrane fluidity of liver microsomes and mitochondria was also observed.The results indicate that the elevations of sGPT and sGST levels were related to enhancement of lipid peroxidation and membrane fluidity in Pred-treated mice.Pretreatment with sodium ferulate(SF)100 mg·kg^-1 partially alleviated the liver lesions as observed by electron microscope observation. The sGPT and sGST levels and liver homogenate MDA content were reduced , and the membrane fluidity of liver microsomes was recovered.But,the membrane fluidity of liver mitochondria was further elevated. The results demonstrate partial inhibitory effect of sodium ferulate on prednisolone- induced liver toxicity.