| 格列吡嗪胶囊的药代动力学及生物利用度研究 |
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| 引用本文： | 陈秋潮,杨春芹,赵彩虹,马永贵,李雪宁,陈伟力.格列吡嗪胶囊的药代动力学及生物利用度研究[J].药学学报,1995,30(6):476-480. |
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| 作者姓名： | 陈秋潮 杨春芹 赵彩虹 马永贵 李雪宁 陈伟力 |
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| 作者单位： | 上海医科大学中山医院药剂科，上海第四人民医院 |
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| 摘 要： | 格列吡嗪胶囊的药代动力学及生物利用度研究陈秋潮，杨春芹，赵彩虹，马永贵，李雪宁，陈伟力（上海医科大学中山医院药剂科２０００３２）格列吡嗪（ｇｌｉｐｉｚｉｄｅ，简称Ｇ）属新的磺酰脲类降糖药，主要用于Ⅱ型（非胰岛素依赖型）糖尿病。其药理作用主要是直接刺激...
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| 关 键 词： | 格列吡嗪胶囊 高效液相色谱法 药代动力学 生物利用度 |
| 收稿时间： | 1994-07-08 |
PHARMACOKINETICS AND BIOAVAILABILITY OF GLIPIZIDE CAPSULES |
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| QC Chen,CQ Yang,CH ChaO,YG Ma,XN Li and WL Chen.PHARMACOKINETICS AND BIOAVAILABILITY OF GLIPIZIDE CAPSULES[J].Acta Pharmaceutica Sinica,1995,30(6):476-480. |
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| Authors: | QC Chen CQ Yang CH ChaO YG Ma XN Li and WL Chen |
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| Abstract: | The pharmacokinetics and
bioavailability of glipizide were studied in 8 healthymaie volunteers
after a single oral dose of 5 mg in capule or in tablet.The plasma
levels of glipizldewere assayed by high performance liquid
chromatography.The concentration time curves of bothpreparations
were fitted to a one compartment model.The pharmacokinetic parameters
of glipizide incapsule and in tablet were shown in tables 2 and 3.The
relative bioavailability of the capsule was109.9%compared with the
tablet. |
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| Keywords: | Glipizide capsule HPLC Pharmacokinetics Bioavailability |
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