| 间硝地平对高血压心肌肥厚老龄鼠肾和肺细胞膜二氢吡啶受体的影响 |
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| 引用本文： | 徐毅,奚涛,饶曼人. 间硝地平对高血压心肌肥厚老龄鼠肾和肺细胞膜二氢吡啶受体的影响[J]. 药学学报, 1995, 30(1): 59-62 |
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| 作者姓名： | 徐毅 奚涛 饶曼人 |
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| 作者单位： | 南京医科大学心血管药理研究室，湖南医科大学心血管生理研究室博士，南京大学生物化学系博士后 |
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| 摘 要： | 间硝地平对高血压心肌肥厚老龄鼠肾和肺细胞膜二氢吡啶受体的影响徐毅，奚涛，饶曼人（南京医科大学心血管药理研究室２１００２９）间硝地平（ｍ－ｎｉｆｅｄｉｐｉｎｅ，ｍ－Ｎｉｆ）系我国研制的二氢吡啶（ＤＨＰ）类钙拮抗剂，有扩张血管、降低血压和逆转高血压心肌肥...
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| 关 键 词： | 间硝地平 高血压 受体 二氢吡啶 |
| 收稿时间： | 1994-04-21 |
EFFECTS OF m-NIFEDIPINE ON DIHYDROPYRIDINE BINDING SITES IN THE CELL MEMBRANES OF KEDNEY AND LUNG FROM LEFT VENTRICULAR HYPERTROPHIED ELDEKLY RATS |
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| Y Xu,T Xi and MR Rao. EFFECTS OF m-NIFEDIPINE ON DIHYDROPYRIDINE BINDING SITES IN THE CELL MEMBRANES OF KEDNEY AND LUNG FROM LEFT VENTRICULAR HYPERTROPHIED ELDEKLY RATS[J]. Acta pharmaceutica Sinica, 1995, 30(1): 59-62 |
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| Authors: | Y Xu T Xi MR Rao |
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| Abstract: | Effects of m-nifedipine(m-Nif)on the affinity and density of dihydropyridine(DHP)binding sites in the cell membranes of kidney and lung were investigated using the LVH(leftventricular hypertrophy )induced by Goldblatt( 2k-1c)renovascular hypertension in elderly rats.m-Nif markedly reduced blood pressure , left ventricular weight ,and decreased the density(Bmax)ofDHP binding sites in the cell membranes of kidney and lung from 699±112,759±35 fmol·mg-1protein to 482±29,38l ± 33 fmol·mg-1. protein, No difference was ohserved between groups indissociation constant(KD )values of DHP binding sites.The results suggest that m-Nif could markedlydecrease DHP binding sites in the membranes of kidney and lung from cardiac hypertrophied elderlyrats. |
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| Keywords: | m-nifedipine Hypertension Receptor Dihydropyridine |
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