| 磷脂酶A2抑制剂的三维构效关系研究 |
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| 引用本文： | 邓巧临,曹斌,来鲁华,唐有祺.磷脂酶A2抑制剂的三维构效关系研究[J].药学学报,1995,30(6):428-434. |
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| 作者姓名： | 邓巧临 曹斌 来鲁华 唐有祺 |
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| 作者单位： | 北京大学化学系 |
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| 基金项目： | “863”高技术计划资助 |
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| 摘 要： | 对近两年来专利报道中三个系列24个磷脂酶A2抑制剂进行了三维构效关系的研究,采用分子场比较分析方法(CoMFA)寻找结构与活性之间的关系,建立了一个可靠的构效关系模型,为活性分子的进一步修饰和改造提供了信息。
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| 关 键 词： | 磷脂酶A2 抑制剂 构效关系 |
| 收稿时间： | 1994-07-06 |
COMPARATIVE MOLECULAR FIELD ANALYSIS(CoMFA)STUDY ON KNOWN INHIBITORS OF PHOSPHOLIPASE A2 |
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| QL Deng,B Cao,LH Lai and YQ Tang.COMPARATIVE MOLECULAR FIELD ANALYSIS(CoMFA)STUDY ON KNOWN INHIBITORS OF PHOSPHOLIPASE A2[J].Acta Pharmaceutica Sinica,1995,30(6):428-434. |
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| Authors: | QL Deng B Cao LH Lai and YQ Tang |
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| Abstract: | Phospholipase A2(PLA2) plays an important role in the inflammation process.Inhibition of PLA2 may provide a possible therapeutic method for inflammation disorders.Three seriesof known inhibitors of PLA2(altogether 24 compounds)which have similar structural groups,wereselected from the patents.Comparative molecular field analysis(CoMFA)study was carried out onthese molecules and a positive structure-activity relationship has been derived.The results show thatthe steric fields gave more contribution to the model than the electrostatic fields.The analysis providesvaluable information for the design of inhibitors with more potent activity. |
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| Keywords: | Phospholipase A2 Inhibitors Structure-activity relationship |
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