26种药物的四苯硼盐体系的电位滴定曲线

以自制的涂碳空白PVC膜电极为指示电极、四苯硼钠标准溶液为滴定剂,测试了26种药物的电位滴定曲线,进行了回收率和方法对比实验,获良好结果。本文还用三参数法处理了所有的电位滴定曲线,评价了不同滴定体系的灵敏度及其优劣次序。

POTENTIOMETRIC TITRATION CURVES OF 26 DRUGS

In this paper,the potentiometric titration curves of 26 drugs and recoveries weremeasured by using coated carbon PVC membrane electrode as indicating electrode and standard solutionof sodium tetraphenylboron as titrant.These curves were calculated by the parameter methtod and thesuperiority sequence was evaluated. The results show that the superiority sequence of the poten-tiometric titration curves depends on the structure of the cations of the drugs,1.0×10^-5mol·L^-1 ofthe drugs can be measured for methylene blue, berberine , cyproheptadine and benzhexol;1.0×10-4mol·L^-1 for diphenhydramine and aconitine;1.0×10-3 mol·L^-1 for brucine,tetramisol,chlorphe-namine maleate and procaine;5.0×10-3mol·L^-1 for ketamine,vitamin B6 and vitamin B₁; andwhen ionized by iedomethane,1.0×10-5mol·L^-1 for clotrimazole,1.0×10-3 mol·L^-1 forthiamazole , atropine and physostigmine;5.0×10-3mol·L^-1 for amidopyrine and imidazole.