丹酚酸A对大鼠半乳糖性白内障形成的抑制作用

业已证明,丹酚酸A有较强的抗氧化和清除自由基等多方面的作用。本实验用大鼠半乳糖性白内障模型,研究局部应用丹酚酸A对白内障形成的影响。结果表明,局部用0.05%的丹酚酸A(每日滴眼两次)对白内障的形成有一定的抑制作用,使白内障形成过程减缓。而且给药组动物晶体内过氧化氢和脂质过氧化产物(MDA)含量减少,蛋白巯基和总巯基增加。体外实验表明,丹酚酸A对醛糖还原酶有一定抑制作用。以上结果提示,丹酚酸A可通过不同途径抑制白内障的形成,对糖性白内障的防治有一定意义。

PREVENTON OF GALACTOSE-INDUCED CATARACTOGENESIS IN RATS BY SALVIANOLIC ACID

Salvianolic acid A has been demonstrated to have efficient antioxidative and freeradical scavenging effects. In the present experiments,the preventive effects of salvianolic acid A ongalactose-induced cataract in rats were investigated. Dropping 0.05%salvianolic acid A in the eyes(two times a day) was found to delay the development of cataract. The contents of MDA and H2O2 inthe cataract lens were decreased in salvianolic acid A treated rats. The Protein and non-protein thiols inthe cataract lens of the salvianolic acid A treated rats were higher than those of control rats. In in vitroexperiments salvianolic acid A was shown to inhibit aldose reductase activity. These results indicatethat sallvianolic acid A can prevent galactose-induced cataract by antioxidation and inhibition of aldose reductase.