含铋剂四联疗法治疗消化性溃疡幽门螺杆菌感染的疗效分析

目的 探讨含铋剂四联疗法治疗消化性溃疡幽门螺杆菌感染的临床疗效.方法 收集本院2013年7月至2015年4月收治的消化性溃疡幽门螺杆菌感染患者208例前瞻性研究且随机分为两组,每组104例,实验组患者给予阿莫西林+泮托拉唑+呋喃唑酮+胶体果胶铋四联疗法治疗,对照组患者则给予阿莫西林+泮托拉唑+克拉霉素三联疗法治疗,比较两组患者胃溃疡与十二指肠溃疡治疗效果评价、幽门螺杆菌根除率与药物不良反应情况等.结果 实验组患者胃溃疡(95.00％)与十二指肠溃疡(98.44％)治疗效果评价显著优于对照组(75.00％,83.33％),差异具有统计学意义(P＜0.01);实验组患者胃溃疡(90.00％)与十二指肠溃疡(95.31％)幽门螺杆菌根除率显著高于对照组(68.18％,71.67％),差异具有统计学意义(P＜0.01);两组患者药物不良反应情况比较(6.72％ vs.3.84％),差异无统计学意义(P＞0.05).结论 含铋剂四联疗法治疗消化性溃疡幽门螺杆菌感染的临床疗效显著,且安全性较好,具有借鉴性.

Bismuth-containing quadruple therapy for peptic ulcer complicated with helicobacter pylori infection

Objective To investigate the clinical curative effect of bismuth-containing quadruple therapy for peptic ulcer complicated with helicobacter pylori infection.Methods 208 patients with peptic ulcer complicated with helicobacter pylori infection admitted into our hospital from July,2013 to April,2015 were selected for prospective study and were randomly divided into an experimental group and a control group,104 cases for each group.The experimental group was treated with quadruple therapy of amoxicillin,pantoprazole,furazolidone,and colloidal bismuth pectin and the control group with triple therapy of amoxicillin,pantoprazole,and clarithromycin.The treatment effectiveness evaluation of gastric ulcer,andduodenal ulcer,helicobacter pylori eradicated rate,conditions of drug adverse reactions,etc.of these two groups were compared.Results The significance of thetreatment effectiveness evaluation of gastric ulcer and duodenal ulcerwas better in the experimental group (95.00％ and 98.44％) than in the control group(75％ and 83.33％),with statistical differences(P＜0.01).The helicobacter pylori eradicated rates of gastric ulcer and duodenal ulcer were better in the experimental group (90.00％ and 95.31％) than in the control group(68.18％ and 71.67％),with statistical differences(P＞0.01).There was no statistical difference in the incidence of drug adverse reactions bwtween these two groups(6.72％ vs.3.84％,P＞0.05).Conclusions Bismuth-containing quadruple therapy in the treatment of peptic ulcer with helicobacter pylori infection has significant clinical curative effect and better safety.It is of reference.