基质金属蛋白酶-2在喉鳞状细胞癌中的表达及临床意义

目的：探讨基质金属蛋白酶（MMP）-2在喉鳞状细胞癌（LSCC）中的表达及临床意义。方法：采用免疫组织化学SP法检测了63例LSCC及其中20例癌旁安全缘正常组织（ASM）和18例声带息肉（VCP）中MMP2的表达。结果：MMP2在LSCC、VCP和ASM中的阳性率分别是66．7％、33．3％、15．0％，3者之间均差异有统计学意义（均P〈0．05）；在I．SCC不同病理分级Ⅰ、Ⅱ、Ⅲ级间表达存在差异（均P〈0．05）；在LSCC淋巴结转移与非转移者间的表达差异无统计学意义（P〉0．05）；在不同临床分期及不同年龄组间的表达差异无统计学意义。结论：MMP-2可能只在LSCC发生及发展中起重要作用，而与LSCC的转移无关。

Expression and clinical significance of matrix metalloproteinase-2 in laryngeal squamous cell carcinoma

OBJECTIVE: To investigate the relationship between the expression of matrix metalloproteinase-2 (MMP-2) and clinical significance of laryngeal squamous cell carcinomas (LSCC). METHOD: Expression of the MMP-2 was detected by immunohistochemical method in 63 cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal cord polyp(VCP). RESULT:The positive percentage of active MMP-2 expression were 66.7%,33. 3% and 15. 0%, in LSCC,VCP and ASM respectively. Significant differences ( P <0. 05) were observed among the three group; there was a significant differences in the expression of MMP-2 among the different pathologic degree I , II , Ill ;no significant difference in the expression of MMP-2 between lymphoid metastasis and no lymphoid metastasis( P >0. 05) ;Age and clinical stage did not change the expressions of the MMP-2 expression( P <0. 05). CONCLUSION: MMP-2 probably plays an important role in the carcinogenesis and progression of LSCC. But it may be an unnecessary factor in the metastases of LSCC.