建立我国规模化无菌动物高效研究应用体系

无菌动物与宏基因组技术是驱动人体健康微生物组研究的两大动力。没有无菌动物菌群（株）移植模型，就无法确立菌群与疾病的因果关系；没有无菌动物，就没有菌群与人体疾病研究飞速发展的今天与明天。无菌动物应用已形成有菌与无菌动物比较、菌群（株）移植、基因工程动物无菌化、无菌动物发育四种通用研究模式，研究模式的标准化将加大无菌动物研究应用规模及速度。本课题组经过十几年努力，已建成国内体量大、技术体系稳定、服务单位多、具有较大影响力的无菌动物平台，为国内生物医学、畜牧、食品微生物组科学问题解决提供了有力支撑。但是，目前我国无菌动物规模小、效率低、供用平台与应用条件分离，无菌动物基础理论与技术体系尚待发展，难以满足日益增长的应用需求。亟待建立规模化无菌动物高效研究应用体系，以适应我国微生物组研究高速发展。

Establishment of a highly effective large-scale germ-free animal efficiency research and application system in China

Germ-free animals and metagenomic technology are the two major wheels for the study of microbiome in human health.Without a transplantation model of germ-free animals inoculated with microbiota (bacterial strains),it is impossible to establish the causal relationship between microbiota and diseases.Without germ-free animals,there will be no rapid development of research on the relationship between microbiota and human diseases today and tomorrow.Application of germ-free animals has formed four kinds of general research models,including comparison of conventional and germ-free animals,bacteria (strain) transplantation with germ-free animals,rederivation of germ-free genetic engineering animals,and development of germ-free animals.Standardization of research mode will increase the scale and speed of application of germ-free animals.After ten years of efforts,Professor Wei Hong''s group has built the largest scale,the most stable technical system,most widely used platform of germ-free animal in our country,which have provided a strong support in our country for scientific problem solving in the fields including animal husbandry,biomedicine,and food microbiology.At present,the germ-free animals are in small scale,low in efficiency,and the platform is separated from the application conditions.The basic theory and technical system of germ-free animals are still to be developed,and it is difficult to meet the growing demand for application.Establishment of an efficient large-scale research and application system of germ-free animals will meet the needs of rapid development of microbiome research in China.