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A bypass mechanism of abiraterone-resistant prostate cancer: Accumulating CYP17A1 substrates activate androgen receptor signaling |
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| Authors: | Jan M. Moll Jinpei Kumagai Martin E. van Royen Wilma J. Teubel Robert J. van Soest Pim J. French Yukio Homma Guido Jenster Ronald de Wit Wytske M. van Weerden |
| Affiliation: | 1. Department of Urology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands;2. Department of Urology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands Department of Urology, University of Tokyo, Tokyo, Japan;3. Department of Pathology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands Department of Erasmus Optical Imaging Centre, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands Department of Cancer Treatment Screening Facility, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands;4. Department of Cancer Treatment Screening Facility, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands Department of Neurology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands;5. Department of Urology, University of Tokyo, Tokyo, Japan;6. Department of Medical Oncology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands |
| Abstract: | |
| Keywords: | abiraterone resistance androgen receptor activation castration-resistant prostate cancer cytochrome P450, family 17, subfamily A, polypeptide 1 inhibitor TAK700 |