| 无菌动物在肠-肝轴研究中的应用前景 |
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| 引用本文： | 魏应凤,梁雁,林臣鸿,章旭君,陈佳宁,汤建华,顾秋平,刁宏燕.无菌动物在肠-肝轴研究中的应用前景[J].实验动物与比较医学,2017,25(6):671-675. |
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| 作者姓名： | 魏应凤 梁雁 林臣鸿 章旭君 陈佳宁 汤建华 顾秋平 刁宏燕 |
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| 作者单位： | 浙江大学医学院附属第一医院传染病诊治国家重点实验室, 感染性疾病诊治协同创新中心, 杭州 310003;赣州市人民医院, 赣州 341000,浙江大学医学院附属第一医院传染病诊治国家重点实验室, 感染性疾病诊治协同创新中心, 杭州 310003,浙江大学医学院附属第一医院传染病诊治国家重点实验室, 感染性疾病诊治协同创新中心, 杭州 310003,浙江大学医学院附属第一医院传染病诊治国家重点实验室, 感染性疾病诊治协同创新中心, 杭州 310003,浙江大学医学院附属第一医院传染病诊治国家重点实验室, 感染性疾病诊治协同创新中心, 杭州 310003,赣州市人民医院, 赣州 341000,赣州市人民医院, 赣州 341000,浙江大学医学院附属第一医院传染病诊治国家重点实验室, 感染性疾病诊治协同创新中心, 杭州 310003 |
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| 基金项目： | 国家自然科学基金面上项目（No.81571953）；浙江省医药卫生科技项目省部共建计划（No.2015118507）；浙江省自然基金面上项目（No.LY16H190002）。 |
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| 摘 要： | 肠道和肝之间通过肠-肝轴紧密相连，肠道疾病可以影响肝功能，肝疾病也可以诱发肠道菌群和功能的改变。无菌动物是一种身体所有部位都没有任何活的细菌、真菌、病毒及寄生虫的动物，无菌动物的出现为研究微生物与宿主之间的相互作用提供了有力的实验工具。同时，由于无菌动物缺乏正常肠道菌群的特点，它在肠-肝轴的研究中也起到了极大的推进作用。本文将对无菌动物在肠-肝轴中的应用前景做简要综述。
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| 关 键 词： | 无菌动物 肠-肝轴 肠道菌群 |
| 收稿时间： | 2017/10/9 0:00:00 |
Prospects of germ-free animals in the study of gut-liver axis |
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| WEI Ying-feng,LIANG Yan,LIN Chen-hong,ZHANG Xu-jun,CHEN Jia-ning,TANG Jian-hu,GU Qiu-ping and DIAO Hong-yan.Prospects of germ-free animals in the study of gut-liver axis[J].Laboratory Animal and Comparative Medicine,2017,25(6):671-675. |
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| Authors: | WEI Ying-feng LIANG Yan LIN Chen-hong ZHANG Xu-jun CHEN Jia-ning TANG Jian-hu GU Qiu-ping and DIAO Hong-yan |
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| Institution: | State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China;Ganzhou People''s Hospital, Ganzhou 341000,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China,Ganzhou People''s Hospital, Ganzhou 341000,Ganzhou People''s Hospital, Ganzhou 341000 and State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China |
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| Abstract: | Intestine and liver have very closely relationship due to the gut-liver axis,intestinal disease can affect the liver function,and the liver disease may also induce intestinal disorders.The germ-free animals have no living bacteria,fungi,viruses and parasites.The appearance of germ-free animals provides a powerful experimental tool for studying the interaction between the host and the intestinal microorganisms.At the same time,due to the characteristics of lacking normal intestinal flora,germ-free animals play a great role in promoting the study of gut-liver axis.In this paper,we will briefly review the application prospects of germ-free animals in the research of gut-liver axis. |
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| Keywords: | Germ-free animal Gut-liver axis Intestinal microflora |
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