玛咖提取物对小鼠毒性及免疫器官的影响

目的 探讨玛咖提取物对小鼠毒性及免疫器官的影响。方法 给予BALB/c小鼠玛咖提取物15 d,观察玛咖对小鼠的毒性作用,称量胸腺和脾重量。结果24 h内小鼠口服累计剂量为320 g/(kg·bw),未见动物出现任何毒性反应。给予玛咖提取物16.0、32.0、64.0 g/(kg·bw)15 d,胸腺重量比对照组分别增加了36.84%、89.47%、107.89%,脾脏重量分别增加了44.83%、62.01%、89.66%,小鼠碳粒廓清指数分别增加了30.85%、42.55%、54.79%,血清溶血素值分别增加了11.64%、20.03%、31.51%,与对照组相比,差异有显著性(P<0.05~0.01)。结论 玛咖提取物具有增加免疫器官重量和提高免疫功能的作用,且毒性较低。

Effect of Maca extract on the toxicity and immune organs in mice

Objective To study the effect of Maca extract on toxicity and immune organs in mice. Methods One hundred and fifty SPF BALB/c mice (male:female=1:1, body weight 20-22 g) were used in this study. The mice received Maca extract for 15 days, and the maca toxic effect on mice, and the thymus and spleen weights were observed. Results At 24 hours after oral administration of Maca extract in an accumulated dose of 320 g/kg·bw, no toxic response was seen in the mice. After administration of Maca extract in a dose of 16.0, 32.0, and 64.0 g/kg·bw for 15 days, the thymus weight was increased by 36.84%, 89.47% and 107.89%, respectively, the spleen weight was increased by 44.83%,62.01%, and 89.66%, respectively, the carbon clearance index was increased by 30.85%, 30.85% and 42.55%, respectively, and the serum hemolysin value was increased by 11.64%, 20.03% and 31.51%, respectively, in the experimental mice, significantly higher than those of the control group (P < 0.05 or P < 0.01 for all). Conclusions Maca extract exerts an enhancing effect on the immune organ weights and improve the immune function, and is associated with a lower toxicity.