| 严重的糖尿病血管病变的发生机制及其动物模型制作进展 |
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| 引用本文： | 冯丽帅,马旭,王建波.严重的糖尿病血管病变的发生机制及其动物模型制作进展[J].实验动物与比较医学,2016,24(3):327-331. |
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| 作者姓名： | 冯丽帅 马旭 王建波 |
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| 作者单位： | 上海交通大学附属第六人民医院介入放射科, 上海 200233;上海交通大学附属第六人民医院介入放射科, 上海 200233;上海交通大学附属第六人民医院介入放射科, 上海 200233 |
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| 摘 要： | 2型糖尿病(DM)并发的动脉粥样硬化(AS)由于具有斑块不稳定、供血区缺血严重及治疗后再狭窄率高等特点成为导致2型DM患者死亡及截肢最常见病因。对2型DM血管并发症制定并实施针对性强的治疗方案对降低此类疾病对人类健康的危害有重要意义。而2型DM背景下严重的血管病变动物模型的建立,则为研究并进一步实施2型DM血管并发症治疗方案提供了实验基础。本文首先对2型DM并发的严重的血管病变发生机制进行探讨,进一步对现阶段国内外建立此类血管病变动物模型的实验方法进行综述。
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| 关 键 词： | 糖尿病 血管病变 动物模型 |
| 收稿时间： | 2015/12/27 0:00:00 |
Mechanism and research progress of severe diabetic vasculopathy and related experimental animal studies |
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| FENG Li-shuai,Ma Xu and WANG Jian-bo.Mechanism and research progress of severe diabetic vasculopathy and related experimental animal studies[J].Laboratory Animal and Comparative Medicine,2016,24(3):327-331. |
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| Authors: | FENG Li-shuai Ma Xu and WANG Jian-bo |
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| Institution: | Department of Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People''s Hospital, Shanghai 200233, China;Department of Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People''s Hospital, Shanghai 200233, China;Department of Interventional Radiology, Shanghai Jiaotong University Affiliated Sixth People''s Hospital, Shanghai 200233, China |
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| Abstract: | Diabetes mellitus (DM) complicated with atherosclerosis (AS) is the most common cause of amputation and death in patients with type 2 DM due to the instability of plaque, severe ischemia and the high rate of restenosis after treatment. It is important to reduce the diabetic vascular complications in those patients. Establishment of animal models of severe diabetic vasculopathy will provide an experimental basis for further studies on those complications. In this paper, we will firstly discuss the mechanism of the development of severe diabetic vasculopathy and then review the methods referring to the establishment of this kind of animal models worldwide. |
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| Keywords: | Diabetes mellitus Vasculopathy Animal model |
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