子宫内膜异位症对小鼠生育能力的影响

【摘要】：目的：建立子宫内膜异位症小鼠模型，观察子宫内膜异位症对模型小鼠妊娠能力的影响。方法：通过“腹腔 皮下”同系异体子宫内膜注射法建立子宫内膜异位症小鼠模型，与假手术组、空白组比较，观察其妊娠率及活胎率，观察子宫内膜异位症对模型小鼠妊娠能力的影响。结果：建模2周后，小鼠皮下和腹腔均见有子宫内膜异位病灶生成，模型组、假手术组和空白组，共三组。通过生育功能检测，三组妊娠率差异有显著性意义（P<0.05）。三组的活胎数差异有显著性意义（P<0.05）。结论：成功建立子宫内膜异位症小鼠模型，并证实子宫内膜异位症可影响模型小鼠生育功能。

Effects of endometriosis on the reproductive ability of mice

Objective The aim of the study was to establish a mouse model of endometriosis, and to observe the effects of endometriosis on the reproductive ability in the mice. Methods The mouse models of endometriosis was established by subcutaneous and intraperitoneal injection of heterogenous endometrium. The pregnancy rate and live embryo number in the experimental, sham operation and blank groups were observed and compared, and the effects of endometriosis on reproductive ability of the mice were evaluated. Results Two weeks after the establishment of the mouse model of endometriosis, there were lesions in the peritoneal cavity and subcutaneous tissue of the mice. Compared the pregnancy rates among the model group, sham operation group and blank group, the differences were statistically significant (P<0.05). Compared the live embryo number in the three groups, there were also significant differences (P<0.05). Conclusions A mouse model of endometriosis is successfully established, and it demonstrates that endometriosis may affect the reproductive ability of mice.