| 新生儿坏死性小肠结肠炎动物模型研究进展 |
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| 引用本文： | 杨凯蒂,贺雨,曾本华,肖洒,艾青,魏泓,余加林. 新生儿坏死性小肠结肠炎动物模型研究进展[J]. 实验动物与比较医学, 2017, 25(6): 689-692 |
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| 作者姓名： | 杨凯蒂 贺雨 曾本华 肖洒 艾青 魏泓 余加林 |
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| 作者单位： | 重庆医科大学附属儿童医院新生儿中心, 重庆 400014;儿童发育疾病研究教育部重点实验室, 重庆 400014;儿童发育重大疾病国家国际科技合作基地, 重庆 400014;儿科学重庆重点实验室, 重庆 410014,重庆医科大学附属儿童医院新生儿中心, 重庆 400014;儿童发育疾病研究教育部重点实验室, 重庆 400014;儿童发育重大疾病国家国际科技合作基地, 重庆 400014;儿科学重庆重点实验室, 重庆 410014,第三军医大学基础部实验动物学教研室, 重庆 400038,重庆医科大学附属儿童医院新生儿中心, 重庆 400014;儿童发育疾病研究教育部重点实验室, 重庆 400014;儿童发育重大疾病国家国际科技合作基地, 重庆 400014;儿科学重庆重点实验室, 重庆 410014,重庆医科大学附属儿童医院新生儿中心, 重庆 400014;儿童发育疾病研究教育部重点实验室, 重庆 400014;儿童发育重大疾病国家国际科技合作基地, 重庆 400014;儿科学重庆重点实验室, 重庆 410014,第三军医大学基础部实验动物学教研室, 重庆 400038,重庆医科大学附属儿童医院新生儿中心, 重庆 400014;深圳大学总医院儿科, 深圳 518055;儿童发育疾病研究教育部重点实验室, 重庆 400014;儿童发育重大疾病国家国际科技合作基地, 重庆 400014;儿科学重庆重点实验室, 重庆 410014 |
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| 摘 要： | 新生儿坏死性小肠结肠炎（NEC）是新生儿时期严重的胃肠道疾病，病死率高，多见于早产儿，极低出生体重儿，但确切病因及发病机制尚未阐明。积极探寻其发病机制，需建立可靠的动物模型以助于对该病的病因、发病机制及防治等各方面进行深入研究，以改善NEC患儿预后有重要意义。
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| 关 键 词： | 坏死性小肠结肠炎 动物模型 新生儿 |
| 收稿时间： | 2017-10-13 |
Progress in research on animal models of neonatal necrotizing enterocolitis |
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| YANG Kai-di,HE Yu,ZENG Ben-hu,XIAO S,AI Qing,WEI Hong and YU Jia-lin. Progress in research on animal models of neonatal necrotizing enterocolitis[J]. Laboratory Animal and Comparative Medicine, 2017, 25(6): 689-692 |
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| Authors: | YANG Kai-di HE Yu ZENG Ben-hu XIAO S AI Qing WEI Hong YU Jia-lin |
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| Affiliation: | Department of Neonatology, Children''s Hospital of Chongqing Medical University, Chongqing 400014, China;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014;China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014;Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014,Department of Neonatology, Children''s Hospital of Chongqing Medical University, Chongqing 400014, China;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014;China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014;Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014,Department of Laboratory Animal Science, College of Basic Medicine, Third Military Medical University, Chongqing 400038,Department of Neonatology, Children''s Hospital of Chongqing Medical University, Chongqing 400014, China;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014;China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014;Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014,Department of Neonatology, Children''s Hospital of Chongqing Medical University, Chongqing 400014, China;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014;China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014;Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014,Department of Laboratory Animal Science, College of Basic Medicine, Third Military Medical University, Chongqing 400038 and Department of Neonatology, Children''s Hospital of Chongqing Medical University, Chongqing 400014, China;Shenzhen University General Hospital, Shenzhen 518055;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014;China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014;Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014 |
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| Abstract: | Neonatal necrotizing enterocolitis (NEC) is a severe gastrointestinal disease with high mortality.Studies have suggested that NEC are associated with prematurity and very-low birth weight,but the exact etiology and pathogenesis has not been elucidated.Therefore,it is important to build an ideal NEC model to explore the pathogenesis and prevention measures of NEC to reduce the incidence and severity of NEC. |
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| Keywords: | Neonatal necrotizing enterocolitis Animal model |
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