MicroRNA-424在肿瘤发生中的作用和机制研究进展

MiR-424是miR-16家族成员。近年研究表明miR-424与肿瘤的发生、发展及治疗预后密切相关。本文对miR-424在乳腺癌、宫颈癌、肺癌、肝癌及结直肠癌等多种肿瘤及白血病中的表达变化、作用及机制进行综述。研究发现miR-424的表达受多种因素的影响,miR-424可作为肿瘤诊断、分期、预后的生物标记物,可用于明确肿瘤范围,也可作为肿瘤的治疗靶物。

Progress in research on the role of microRNA-424 in carcinogenesis and its related mechanism

A member of miR-16 family, miR-424 is found to closely relate with genesis, progress, prognosis and therapy of tumors. This article reviews the expression changes, roles and possible regulating mechanisms of miR-424 in leukemia and multiple tumors such as breast tumor, cervical cancer, lung carcinoma, liver carcinoma and colorectal cancer. Recent studies have demonstrated that the expression of miR-424 is affected by many factors, and miR-424 could be a biomarker of diagnosis, stages and prognosis in tumors, identify the area of tumor, and be the target of therapy.