Combination chemotherapy for unresectable hepatoblastoma in children |
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| Authors: | Shuhei Ogita MD Kazuaki Tokiwa Toshio Takahashi Shinsaku Imashuku Tadashi Sawada |
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| Affiliation: | (1) First Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji Kawaramachi, Kamigyo-ku, 602 Kyoto, Japan;(2) Department of Pediatric, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji Kawaramachi, Kamigyo-ku, 602 Kyoto, Japan;(3) Division of Surgery, Children's Research Hospital, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji Kawaramachi, Kamigyo-ku, 602 Kyoto, Japan |
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| Abstract: | Combination chemotherapy (adriamycin, vincristine, cyclophosphamide, etc.) was prescribed for two patients with initially unresectable hepatoblastoma. A significant reduction in tumor size occurred, and subsequent successful resection was feasible in one, although in the other the regreesed tumor remained inoperable due to the link to the hepatic veins. The survival time for these patients was 9 months after operation and 41 months from diagnosis, respectively. Preoperative combination chemotherapy for initially unresectable hepatoblastoma facilitates surgical removal under more favorable conditions of a decreased tumor size. |
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| Keywords: | hepatoblastoma combined anticancer chemotherapy |
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