| 龙须藤提取物对胶原诱导性关节炎模型大鼠的影响 |
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| 引用本文： | 郑海音,徐伟,李煌,褚克丹,陈立典,张玉琴.龙须藤提取物对胶原诱导性关节炎模型大鼠的影响[J].福建中医学院学报,2013,23(1):31-34. |
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| 作者姓名： | 郑海音 徐伟 李煌 褚克丹 陈立典 张玉琴 |
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| 作者单位： | 郑海音 (福建中医药大学中西医结合学院,福建福州,350122)； 徐伟 (福建中医药大学药学院,福建福州,350122)； 李煌 (福建中医药大学药学院,福建福州,350122)； 褚克丹 (福建中医药大学药学院,福建福州,350122)； 陈立典 (福建中医药大学,福建福州,350122)； 张玉琴 (福建中医药大学药学院,福建福州,350122)； |
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| 基金项目： | 国家自然科学基金资助课题(项目编号：81001624),福建省科技厅重大专项(项目编号：2009YZ0001-1-1)福建省科技厅科技创新平台项目(项目编号：2010Y2004) |
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| 摘 要： | 目的研究龙须藤乙酸乙酯提取物对胶原诱导性关节炎模型大鼠滑膜组织中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)的影响,探讨其作用机理。方法建立胶原诱导性关节炎(CIA)大鼠模型,观察大鼠足趾肿胀度的变化,用免疫组化法检测大鼠踝关节滑膜组织中TNF-α、IL-6、IL-8的含量。结果龙须藤乙酸乙酯提取物能抑制大鼠足趾肿胀及滑膜组织中TNF-α、IL-6及IL-8的表达。结论龙须藤乙酸乙酯提取物对类风湿性关节炎有一定的治疗作用,其作用机理是降低滑膜组织中TNF-α、IL-6、IL-8的表达水平。
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| 关 键 词： | 龙须藤 胶原诱导性关节炎 肿瘤坏死因子-α 白细胞介素-6 白细胞介素-8 |
Effects of Ethyl Acetate Extracts from Bauhinia championii(Benth.) Benth.on Rats with Collagen-induced Arthritis |
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| Institution: | ZHENG Haiyin1,XU Wei2,LI Huang2,et al(1.College of Integrative Medicine,FUTCM,Fuzhou,Fujian 350122,China;2.College of Pharmacy,FUTCM,Fuzhou,Fujian 350122,China) |
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| Abstract: | Objective To investigate the effect of ethyl acetate extracts from Bauhinia championii(Benth.) Benth.on levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-8(IL-8) in synovial tissue of rats with collagen-induced arthritis,and and explore the mechanism.Methods Rats model of collagen-induced arthritis was builded,swelling degree of toes was observed and the levels of TNF-α,IL-6 and IL-8 in synovial tissue of rat ankle joint were detected by immunohistochemistry analysis.Results The ethyl acetate extracts from Bauhinia championii(Benth.) Benth.could inhibit rat toe swelling,and decrease the levels of TNF-α,IL-6 and IL-8.Conclusion The ethyl acetate extracts from Bauhinia championii(Benth.) Benth.has certain effect on polyarthritis destruens,and the mechanism is probably related with the effect of decreasing the levels of TNF-α,IL-6 and IL-8. |
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| Keywords: | Bauhinia championii(Benth ) Benth collagen-induced arthritis TNF-α IL-6 IL-8 |
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