| 聚羟基丁酸及其共聚物在体内组织相容性和降解率的实验研究 |
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| 引用本文： | 周栋,胡平,汪钢,赵东锷,高百顺. 聚羟基丁酸及其共聚物在体内组织相容性和降解率的实验研究[J]. 武警医学, 2003, 14(4): 210-212 |
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| 作者姓名： | 周栋 胡平 汪钢 赵东锷 高百顺 |
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| 作者单位： | 武警甘肃总队医院胸外科,兰州,730050;清华大学化工系高分子研究所,北京,100084;第四军医大学西京医院心血管外科中心,西安,710032;兰州医学院第一附属医院心脏外科,兰州,730000 |
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| 基金项目： | 国家自然科学基金资助项目(39970733) |
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| 摘 要： | 目的评价作为组织工程心脏瓣膜支架材料的聚羟基丁酸/聚羟基戊酸共聚物(Poly-hydroxybutyrate/hydroxy词erate,PHBV)、聚羟基丁酸(Polyhydroxybutyrate,PHB)两种生物可吸收材料的组织相容性和皮下吸收情况.方法对照研究两种材料经皮下埋植后2、4、6、8和10周的大体观察及组织学检查.结果 PHBV皮下包埋8周仍保持膜状结构,10周完全降解,组织相容性及皮下吸收情况优PHB.结论 PHBV符合组织工程心脏瓣膜支架材料的基本要求.
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| 关 键 词： | 组织相容性 心脏瓣膜 聚羟基丁酸/聚羟基戊酸共聚物 聚羟基丁酸 |
| 收稿时间： | 2002-10-29 |
| 修稿时间： | 2002-10-29 |
Experinental study on absorbability of polyhydroxybutyrate and its copolymer PHBV in rabbits |
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| ZHOU Dong,HU Ping,WANG Gang,ZHAO Donge,and GAO Baishun. Experinental study on absorbability of polyhydroxybutyrate and its copolymer PHBV in rabbits[J]. Medical Journal of the Chinese People's Armed Police Forces, 2003, 14(4): 210-212 |
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| Authors: | ZHOU Dong HU Ping WANG Gang ZHAO Donge and GAO Baishun |
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| Affiliation: | ZHOU Dong,HU Ping,WANG Gang,ZHAO Donge,and GAO Baishun. Department of Thoracic Surgery,Gansu Provincial Corps Hospital,Chinese People's Armed Police Forces.Lanzhou 730000,China |
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| Abstract: | Objective To investigate and evaluate the histocompatibility and absorbability of polyhydroxybutyrate/hydroxyvalerate(PH-BV) and polyhydroxybutyrate(PHB) , as biodegradable stents for tissue engineering heart valve. Methods The two biodegradable polymer stents were macroscopically and histologically examined at 2,4,6,8,10 weeks after hypodermic implantation,and were analysed comparatively. Results PHBV membraneous structure remained at 8 weeks after implantation, and the complete degradation of the polymer occurred by 10 weeks.The histocompatibility and absorbability of PHBV was better than those of PHB. Conclusion PHBV can be used to fabricate three - dimensional, biodegradable heart valve stents. |
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| Keywords: | Histocompatibility Heart valve Poly-hydroxybutyrate/hydroxyvalerate Polyhydroxybulyrate |
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