盐酸利多卡因鼻用温敏型凝胶的制备及其体外释放度研究

目的：研制盐酸利多卡因温敏凝胶并考察其释药机制。方法：以泊洛沙姆P407为凝胶材料，以泊洛沙姆P188、PEG6000调节胶凝温度，并采用正交试验筛选处方，采用数学模型拟合释放曲线。结果：盐酸利多卡因温敏凝胶在32～33℃胶凝，释药行为符合Higuchi方程。结论：盐酸利多卡因温敏凝胶处方设计合理，可进一步研究开发。

Preparation of the Nasal Thermosensible Gels of Lidocaine Hydrochloride and Release Behavior in vitro

Objective： To prepare the nasal thermosensible gels of lidocaine hydrochloride and study the release mechanism. Method： The gels were prepared by using P407 as the gel matrix and P188 and PEG6000 were used to adjust the gelatination temperature. The formulations were screened by the method of orthogonal test. Mathematic models were used to imitate the drug release. Resuit： Nasal thermosensible gels of lidocaine hydrochloride was gelated at the temperature between 32 -33℃ and the dissolution curves in vitro showed that the drug release could be best described by the Higuchi equation. Conclusion： The formulation of the nasal thermo- sensible gels of lidocaine hydrochloride is reasonable and it is worth doing further research.