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| RPS12基因表达与胃癌进展及淋巴结转移的研究 | |
| 引用本文： | 刘言厚,孙秀菊,付浩,郑志红,陈芳杰,徐惠绵,王梅先,孙开来. RPS12基因表达与胃癌进展及淋巴结转移的研究[J]. 中国医科大学学报, 2008, 37(4) |
| 作者姓名： | 刘言厚 孙秀菊 付浩 郑志红 陈芳杰 徐惠绵 王梅先 孙开来 |
| 作者单位： | 1. 中国医科大学,基础医学院医学遗传学教研室,沈阳,110001;庄河市中心医院,病理科,辽宁,庄河,116400 2. 中国医科大学,基础医学院医学遗传学教研室,沈阳,110001 3. 沈阳医院生化教研室,沈阳,110034 4. 中国医科大学实验动物中心,沈阳,110001 5. 中国医科大学,附属第一医院肿瘤科,沈阳,110001 |
| 基金项目： | 国家自然科学基金，国家重点基础研究发展规划(973计划)，辽宁省自然科学基金 |
| 摘 要： | 目的探讨核糖体蛋白S12(RPS12)基因表达与胃癌进展及淋巴结转移的关系。方法采用原位杂交方法检测39例进展期胃癌组织、17例正常胃黏膜中RPS12mRNA表达。结果胃癌中RPS12mRNA表达阳性表达率(87.2%)显著高于正常胃黏膜(17.6%),P<0.01;淋巴结转移阳性的胃癌中RPS12mRNA表达阳性率(96.2%)显著高于淋巴结转移阴性者(69.2%),P<0.05。结论RPS12基因高表达与胃癌进展及淋巴结转移有关。 |
| 关 键 词： | 核糖体蛋白S12 胃癌 原位杂交 |
Study on the Relationship of RPS12 Expression with the Progression and Lymph Node Metastasis of Gastric Cancers |
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| LIU Yan-hou,SUN Xiu-ju,FU Hao,ZHENG Zhi-hong,CHEN Fang-jie,XU Hui-mian,WANG Mei-xian,SUN Kai-lai. Study on the Relationship of RPS12 Expression with the Progression and Lymph Node Metastasis of Gastric Cancers[J]. Journal of China Medical University, 2008, 37(4) | |
| Authors: | LIU Yan-hou SUN Xiu-ju FU Hao ZHENG Zhi-hong CHEN Fang-jie XU Hui-mian WANG Mei-xian SUN Kai-lai |
| Abstract: | Objective To study the relationship of RPS12 expression with the progression and lymph node metastasis of gastric cancers. Methods The RPS12 mRNA expressions in 39 cases of advanced gastric cancer and 17 cases of normal gastric mucosa were detected by in situ hybridization. Results The positive rate of RPS12 mRNA expression in gastric cancers (87.2%)was significantly higher than that in normal gastric mucosa(17.6%),P < 0.01. The positive rate of RPS12 mRNA expression in gastric cancers with lymph node metastasis (96.2%)was significantly higher than that without lymph node metastasis(69.2%), P < 0.05. Conclusion The high expression of RPS12 is correlated with the progression and lymph node metastasis of gastric cancer. |
| Keywords: | RPS12 gene gastric cancer in situ hybridization |
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