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| 先天性心脏病肺动脉高压患儿血浆ET-1、CGRP、TXA_2及肺组织中其受体的变化 | |
| 引用本文： | 蔡宇红,孙国成,毛云英,李宏.先天性心脏病肺动脉高压患儿血浆ET-1、CGRP、TXA_2及肺组织中其受体的变化[J].第三军医大学学报,2010,32(3). |
| 作者姓名： | 蔡宇红 孙国成 毛云英 李宏 |
| 作者单位： | 1. 西安交通大学医学院儿科,西安,710061 2. 第四军医大学西京医院心外科,西安,710033 3. 西安交通大学医学院第二附属医院儿科,西安,710004 4. 西安高新医院心外科,西安,710075 |
| 基金项目： | 陕西省卫生厅科研基金(06049)~~ |
| 摘 要： | 目的探讨左向右分流型先天性心脏病合并肺动脉高压患儿血浆内皮素-1(ET-1)、降钙素基因相关肽(CGRP)及血栓素A2(TXA2)的变化及其受体在肺组织中的变化。方法采集60例左向右分流型先天性心脏病患儿血浆,采用酶免、放射性免疫及ELISA等方法测定ET-1、CGRP和TXB2含量,修补术中取患儿肺组织,采用RT-PCT的方法检测相应受体在肺组织中的表达变化。结果与对照组相比,观察组(先天性心脏病组)患儿血浆ET-1及TXB2的水平明显增高(P<0.05),而血浆CGRP的含量水平则明显降低(P<0.01);与无肺动脉高压组患儿相比中、重度肺动脉高压患儿血浆ET-1和TXB2的含量显著增高,而CGRP的含量则显著降低(P<0.05,P<0.01);经过PGE1治疗14 d后,患儿血浆ET-1和TXB2的含量显著降低(P<0.01),而CGRP的含量则无明显变化(P>0.05)。与无肺动脉高压组患儿相比合并肺动脉高压患儿肺组织中ET-1和TXA2受体的mRNA表达显著增高,而CGRP受体的mRNA表达量则显著降低(P<0.05,P<0.01)。结论ET-1、CGRP和TXA2与左向右分流型先天性心脏病合并肺动... |
| 关 键 词： | 心脏缺损 先天性 高血压 肺性 内皮缩血管肽类 降钙素基因相关肽 血栓烷A2 肺 |
Changes of plasma ET-1, CGRP, TXA2 and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension |
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| Cai Yuhong,Sun Guocheng,Mao Yunying,Li Hong.Changes of plasma ET-1, CGRP, TXA2 and their receptor expression in lung tissue of children with congenital heart disease-associated pulmonary artery hypertension[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(3). | |
| Authors: | Cai Yuhong Sun Guocheng Mao Yunying Li Hong |
| Institution: | 1Department of Paediatrics;College of Medicine;Xi'an Jiaotong University;Xi'an;Shaanxi Province;710061;2Department of Cardiac Surgery;Xijing Hospital;Fourth Military Medical University;710033;3Department of Pediatrics;Second Affiliated Hospital;710004;4Department of Cardiac Surgery;Gaoxin Hospital;710075;China |
| Abstract: | Objective To study the changes of plasma ET-1,CGRP,TXA2 and their receptor expression in lung tissue of children with congenital heart disease-assicated pulmonary artery hypertension.Methods Plasma was collected from 60 children patients.ET-1,CGRP and TXB2 levels were measured by EIA,RIA and ELISA,respectively.Expression of their receptors in the lung tissue was detected by RT-PCR.Results The plasma ET-1 and TXB2 levels were significantly higher in CHD patients than in control children.The plasma CGRP level... |
| Keywords: | congenital heart disease endothelin-1 calcitonin gene related peptide thromboxane B2 pulmonary artery hypertension |
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