开心散对记忆障碍小鼠脑组织一氧化氮、胆碱酯酶含量的影响

研究中药开心散增强记忆、益智健脑的作用机理。复制东莨菪碱所致小鼠记忆获得障碍模型 ,检测脑组织一氧化氮 /一氧化氮合酶 (NO/NOS)和胆碱酯酶 (ChE)含量。结果东莨菪碱记忆获得障碍模型小鼠NO、NOS含量和ChE活性均较对照组升高。应用开心散后能够显著降低小鼠脑组织NO和NOS含量 ,抑制ChE活性。说明开心散可能具有调节胆碱能神经系统活动的功能 ,并通过降低NOS活性和抑制NO生成起到保护神经细胞、促进记忆的作用

Effects of Kaixin Powder on Cerebral Nitric Oxide and Cholinesterase in the Mouse with Dysmnesia

Mouse model of acquired dysmnesia induced by scopolamine was used to study the mechanism of the effects of reinforcing memory and benefiting mentality of Kaixin Powder, with the contents of cerebral nitric oxide (NO), nitric oxide synthase (NOS) and cholinesterase (ChE) as experimental criteria. The results showed that the cerebral NO and NOS contents and the ChE activity were higher in the mice in the model group than those in the mice in the control group; and the cerebral NO and NOS contents and the ChE activity were significantly decreased in the mice in the model group after being treated with Kaixin Powder. The results suggest that Kaixin Powder may adjust the activity of cholinergic nervous system, protect nervous cells and reinforce memory through decreasing the NOS activity and inhibiting the formation of NO.