| 丙酮酸钙对肥胖大鼠脂质代谢及肥胖基因表达产物的影响 |
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| 引用本文： | 陈世伟,刘翠娥,张杰,费炳洪,苏瓒,王海玉,孟光,张焱. 丙酮酸钙对肥胖大鼠脂质代谢及肥胖基因表达产物的影响[J]. 郑州大学学报(医学版), 2003, 38(5): 771-774 |
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| 作者姓名： | 陈世伟 刘翠娥 张杰 费炳洪 苏瓒 王海玉 孟光 张焱 |
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| 作者单位： | 1. 河南省卫生防疫站中心实验室,郑州,450003
2. 郑州大学第一附属医院检验科,郑州,450052 |
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| 摘 要： | 目的探讨丙酮酸钙对肥胖大鼠体重、体脂含量、血脂和血瘦素水平等的影响.方法以高脂饲料诱导大鼠肥胖模型,然后将肥胖模型鼠随机分为4组对照组、低剂量(0.1 g/kg)、中剂量(0.3 g/kg)、高剂量(1.0 g/kg)3个丙酮酸钙组,饲养6周,处死大鼠.观察大鼠体重、睾丸+肾脂肪垫质量、血脂、血糖(Glu)及血瘦素(Leptin)水平等的变化.结果中、高剂量组的动物体重、睾丸+肾脂肪垫、胆固醇(TC)、甘油三酯(TG)及Leptin水平均显著低于对照组 (P<0.05);高剂量组的高密度脂蛋白胆固醇(HDL-C)显著高于对照组(P<0.05);各组间的血糖含量差异无统计学意义.结论丙酮酸钙有改善大鼠肥胖及降低高血脂水平的作用.
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| 关 键 词： | 丙酮酸钙 血脂 瘦素 肥胖 大鼠 |
| 修稿时间： | 2002-11-13 |
Effects of calcium pyruvate on lipid metabolism and product of ob gene in obese rats |
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| CHEN Shiwei ),LIU Cui' e ),ZHANG Jie ),FEI Binghong ),SU Zan ),WANG Haiyu ),MENG Guang ),ZHANG Yan ) )Central Laboratory,Henan Province Sanitation and Anti Epidemic Station,Zhengzhou )Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou. Effects of calcium pyruvate on lipid metabolism and product of ob gene in obese rats[J]. Journal of Zhengzhou University: Med Sci, 2003, 38(5): 771-774 |
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| Authors: | CHEN Shiwei ) LIU Cui' e ) ZHANG Jie ) FEI Binghong ) SU Zan ) WANG Haiyu ) MENG Guang ) ZHANG Yan ) )Central Laboratory Henan Province Sanitation Anti Epidemic Station Zhengzhou )Clinical Laboratory the First Affiliated Hospital Zhengzhou University Zhengzhou |
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| Affiliation: | CHEN Shiwei 1),LIU Cui' e 1),ZHANG Jie 1),FEI Binghong 2),SU Zan 2),WANG Haiyu 1),MENG Guang 1),ZHANG Yan 1) 1)Central Laboratory,Henan Province Sanitation and Anti Epidemic Station,Zhengzhou 450003 2)Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim: To investigate the effects of oral calcium pyruvate (CP) supplement on body weight,lipid metabolism and leptin in obese rats. Methods:Male Wistar obese rats induced by high fat food were randomly allocated into four groups and fed with CP at doses of 0 g/kg,0.1 g/kg, 0.3 g/kg,and 1.0 g/kg respectively for six weeks, and sacrificed finally. Body weight of obese rats, fat pad around kidney and testis, blood lipids, glucose, and leptin were measured. Results:Body weight,fat pad weight, TC,TG, and leptin of 0.3 g/kg and 1.0 g/kg CP supplementation groups decreased obviously compared with control ( P <0.05). The level of HDL C of 1.0 g/kg group was higher than that of control. There was no statistical difference in blood glucose concentration among four groups( P <0.05). Conclusion: The results suggest that CP can decrease weight gain and blood lipids in obese rats. |
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| Keywords: | calcium pyruvate blood lipid leptin obesity rat |
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