| 丙酮酸钙对肥胖大鼠脂质代谢及肥胖基因表达产物的影响 |
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| 引用本文： | 陈世伟,刘翠娥,张杰,费炳洪,苏瓒,王海玉,孟光,张焱.丙酮酸钙对肥胖大鼠脂质代谢及肥胖基因表达产物的影响[J].郑州大学学报(医学版),2003,38(5):771-774. |
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| 作者姓名： | 陈世伟 刘翠娥 张杰 费炳洪 苏瓒 王海玉 孟光 张焱 |
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| 作者单位： | 1. 河南省卫生防疫站中心实验室,郑州,450003
2. 郑州大学第一附属医院检验科,郑州,450052 |
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| 摘 要： | 目的探讨丙酮酸钙对肥胖大鼠体重、体脂含量、血脂和血瘦素水平等的影响.方法以高脂饲料诱导大鼠肥胖模型,然后将肥胖模型鼠随机分为4组对照组、低剂量(0.1 g/kg)、中剂量(0.3 g/kg)、高剂量(1.0 g/kg)3个丙酮酸钙组,饲养6周,处死大鼠.观察大鼠体重、睾丸+肾脂肪垫质量、血脂、血糖(Glu)及血瘦素(Leptin)水平等的变化.结果中、高剂量组的动物体重、睾丸+肾脂肪垫、胆固醇(TC)、甘油三酯(TG)及Leptin水平均显著低于对照组 (P<0.05);高剂量组的高密度脂蛋白胆固醇(HDL-C)显著高于对照组(P<0.05);各组间的血糖含量差异无统计学意义.结论丙酮酸钙有改善大鼠肥胖及降低高血脂水平的作用.
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| 关 键 词： | 丙酮酸钙 血脂 瘦素 肥胖 大鼠 |
| 修稿时间： | 2002年11月13 |
Effects of calcium pyruvate on lipid metabolism and product of ob gene in obese rats |
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| CHEN Shiwei ,LIU Cui' e ,ZHANG Jie ,FEI Binghong ,SU Zan ,WANG Haiyu ,MENG Guang ,ZHANG Yan Central Laboratory,Henan Province Sanitation and Anti Epidemic Station,Zhengzhou Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou.Effects of calcium pyruvate on lipid metabolism and product of ob gene in obese rats[J].Journal of Zhengzhou University: Med Sci,2003,38(5):771-774. |
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| Authors: | CHEN Shiwei LIU Cui' e ZHANG Jie FEI Binghong SU Zan WANG Haiyu MENG Guang ZHANG Yan Central Laboratory Henan Province Sanitation and Anti Epidemic Station Zhengzhou Clinical Laboratory the First Affiliated Hospital Zhengzhou University Zhengzhou |
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| Institution: | CHEN Shiwei 1),LIU Cui' e 1),ZHANG Jie 1),FEI Binghong 2),SU Zan 2),WANG Haiyu 1),MENG Guang 1),ZHANG Yan 1) 1)Central Laboratory,Henan Province Sanitation and Anti Epidemic Station,Zhengzhou 450003 2)Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim: To investigate the effects of oral calcium pyruvate (CP) supplement on body weight,lipid metabolism and leptin in obese rats. Methods:Male Wistar obese rats induced by high fat food were randomly allocated into four groups and fed with CP at doses of 0 g/kg,0.1 g/kg, 0.3 g/kg,and 1.0 g/kg respectively for six weeks, and sacrificed finally. Body weight of obese rats, fat pad around kidney and testis, blood lipids, glucose, and leptin were measured. Results:Body weight,fat pad weight, TC,TG, and leptin of 0.3 g/kg and 1.0 g/kg CP supplementation groups decreased obviously compared with control ( P <0.05). The level of HDL C of 1.0 g/kg group was higher than that of control. There was no statistical difference in blood glucose concentration among four groups( P <0.05). Conclusion: The results suggest that CP can decrease weight gain and blood lipids in obese rats. |
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| Keywords: | calcium pyruvate blood lipid leptin obesity rat |
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