| 吗啡通过突触前机制抑制视上核神经元兴奋性突触传递 |
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| 引用本文： | 王晓斌,胡三觉,鞠躬. 吗啡通过突触前机制抑制视上核神经元兴奋性突触传递[J]. 医学争鸣, 2001, 22(5): 399-402 |
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| 作者姓名： | 王晓斌 胡三觉 鞠躬 |
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| 作者单位： | 第四军医大学全军神经科学研究所, |
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| 基金项目： | 国家自然科学基金资助项目! (3 9770 715 ) |
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| 摘 要： | 目的：研究吗啡对大鼠视上核神经元兴奋性突触后电流（excitatory postsynaptic currents,EPSCs）的影响，并对其突触机制进行探讨，方法采用脑片膜片钳全细胞记录技术，在电压钳状态下，记录吗啡对大鼠视上核神经元EPSCs和mEPSCs(miniature EPSCs)的影响。结果20μmol.L^-1的吗啡可分别使大鼠视上核神经元的EPSCs的频率下降65％，幅度养活，mEPSCs频率下降45％，幅度减少12％，结论吗啡通过突触前机制抑制视上核神经元突触前兴奋性递质的传递。
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| 关 键 词： | 视上核 全细胞记录 吗啡 突触传递 神经元兴奋性突触传递 |
| 文章编号： | 1000-2790(2001)05-0399-04 |
| 修稿时间： | 2000-02-02 |
Presynaptic inhibitory action of morphine on excitatory synaptic transmission in rat SON neurons in brain slices |
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| WANG Xiao-Bin,HU San-Jue,JU Gong. Presynaptic inhibitory action of morphine on excitatory synaptic transmission in rat SON neurons in brain slices[J]. Negative, 2001, 22(5): 399-402 |
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| Authors: | WANG Xiao-Bin HU San-Jue JU Gong |
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| Abstract: | AIM To observe the effects of morphine on the excita tory postsynaptic currents (EPSCs) and miniature EPSCs (mEPSCs) in rat supraoptic nucleus (SON) neurons and to determine its synaptic mechanism. METHODS Using whole-cell voltage-clamp recording technique in brain slices, the EPSCs and mEPSCs of rat SON neurons were recorded, respectively. RESULTS 20 μmol*L -1 morphine decreased the frequency of EPSCs and mEPSCs (EPSCs by 65%, mEPSCs by 45%), and decreased the amplitude of EPSCs by 44% in all SON neurons, but had no effect on the amplitude distribution of mEPSCs. CONCLUSION Morphine in hibits the excitatory transmissions via presynaptic mechanisms in SON neurons from rat brai n slices. |
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| Keywords: | supraoptic nucleus brain slice whole cell recording synaptil transimission |
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