| 小单孢菌C5308脂溶性活性成分B的分离和结构鉴别 |
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| 引用本文： | 杜康平,王静,姜蓉,李宝义,吴剑波. 小单孢菌C5308脂溶性活性成分B的分离和结构鉴别[J]. 中国抗生素杂志, 2000, 25(5): 333-335,385 |
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| 作者姓名： | 杜康平 王静 姜蓉 李宝义 吴剑波 |
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| 作者单位： | 中国协和医科大学,中国医学科学院,医药生物技术研究所,北京100050 |
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| 摘 要： | 本文以“平行菌法”结合“精原细胞法”作为筛选模型,对小单孢菌Ｃ５３０８发酵液脂溶部分的活性成分进行研究。分离得到Ｃ５３０８－Ｂ和Ｃ５３０８－Ｃ两个化合物。通过ＵＶ、ＩＲ、ＭＳ、＾１Ｈ－ＮＭＲ、＾１３Ｃ－ＮＭＲ及ＨＭＢＣ等光谱分析,确定Ｃ５３０８－Ｂ为ＤｙｎｅｍｉｃｉｎＨ。Ｃ５３０８－Ｃ的结构待进一步确定。
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| 关 键 词： | 小单孢菌C5308 DynemicinH 分离 结构鉴别 |
Isolation and structure identification of antibiotics from a Micromonospora strain C5308 |
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| Du Kang-ping,Wang Jing,Jiang Rong,Li Bao-yi,Wu Jian-bo. Isolation and structure identification of antibiotics from a Micromonospora strain C5308[J]. Chinese Journal of Antibiotics, 2000, 25(5): 333-335,385 |
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| Authors: | Du Kang-ping Wang Jing Jiang Rong Li Bao-yi Wu Jian-bo |
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| Abstract: | A blue compound was isolated from the fermentation broth and mycelia of a Micromonospora strain C530 8by using the methods of parallel- bacteria and spermatogonium as the screening model.C530 8- B and C530 8- C were obtained from the mixture of the extract. By extensive studies of its UV,IR,MS,1H- NMR,13C- NMR and HMBC spectra,the structure of C530 8- B was elucidated. It is Dynemicin H which contains an anthraquinone portion. The chemical name is 9,8,14- [1]buten[1]yl[4 ]ylideneanthra[1,2 - b]benz [f]azocine- 19- carboxylic acid,5,8,9,14,15,16- hexahydro- 1,4 ,6,17- tetrahydroxy- 2 0 - methoxy- 18- methyl- 5, 16- dioxo- ,[8S- ( 8.a,9.a,14.a,17S* ,18R* ) ]- . The structural study of C530 8- C was underway. |
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| Keywords: | Micromonospora strain C530 8 Dynemicin H Isolation Structure identification |
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