| 黄芪对实验性肝纤维化组织ICAM-1表达影响的免疫组化研究 |
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| 引用本文： | 王要军,权启镇,孙自勤,齐凤,江学良,张修礼,王东. 黄芪对实验性肝纤维化组织ICAM-1表达影响的免疫组化研究[J]. 中国临床药理学与治疗学, 2000, 5(1): 49-51 |
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| 作者姓名： | 王要军 权启镇 孙自勤 齐凤 江学良 张修礼 王东 |
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| 作者单位： | 济南军区总医院消化科,济南,250031 |
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| 摘 要： | 目的 观察黄芪抗肝纤维化的疗效并探讨其机理。方法 用黄芪治疗CCl4诱导的肝纤维化模型，观察它对血清HA、肝组织纤维化评分及ICAM－1表达的影响。结果 黄芪组肝纤维化评分及血清HA明显低于模型组，肝组织中ICAM－1阳性细胞数明显减少。结论 黄芪有良好的抗肝纤维化作用，其机理可能与其抑制肝细胞中ICAM－1的表达有关。
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| 关 键 词： | 黄芪 肝纤维化 细胞间粘附分子－1 免疫组化 |
ICAM-1 expression in experimental fibrosis tissue affected by Radis Astragali |
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| WANG Yao-Jun,QUAN Qi-Zhen,SUN Zi-Qin,QI Feng,JIANG Xue-Liang,ZHANG Xiu-Li,WANG Dong. ICAM-1 expression in experimental fibrosis tissue affected by Radis Astragali[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2000, 5(1): 49-51 |
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| Authors: | WANG Yao-Jun QUAN Qi-Zhen SUN Zi-Qin QI Feng JIANG Xue-Liang ZHANG Xiu-Li WANG Dong |
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| Abstract: | Aim To observe the antifibrotic effect of Radis Astragali and to explore the mechanism. Methods The fibrosis of animal model was induced with CCl4,and the model animals were treated with Radis Astragali in treatment group and saline in control group respectively. Results The serum hyaluronic acid (HA), fibrosis score and ICAM_1_positive hepatocytes all the decreased in the treatment group as compared to those in the control group.Conclusion Radis Astragali has satisfactory effect on experimental fibrosis. The mechanism may be correlated with its affection on ICAM_1 in liver tissue. |
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| Keywords: | Radis Astragali liver fibrosis therapy ICAM_1 |
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