| 牛磺酸对大鼠心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 杨俭,曹永安,嵇月娥,施文艳.牛磺酸对大鼠心肌缺血再灌注损伤的保护作用[J].中国临床药理学与治疗学,2000,5(4):317-319. |
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| 作者姓名： | 杨俭 曹永安 嵇月娥 施文艳 |
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| 作者单位： | 江苏职工医科大学药理室,南京210029 |
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| 摘 要： | 目的 探讨牛磺酸对大鼠心肌缺血再灌注损伤的保护作用及其机理。方法 采用在体大鼠冠脉结扎后再通的方法，观察牛磺酸对大鼠心肌缺血再灌注后心肌梗塞的范围，血清和心肌中SOD活性、MDA和NO含量的影响。结果 牛磺酸可明显减少大鼠心肌缺血再灌注的心肌梗塞范围（P＜0．05，0．01），提高大鼠心肌缺血再灌注后血清和心肌中的SOD活性（P＜0．01），降低心肌和血清中MDA和NO含量（P＜0．05，0．01）。结论 牛磺酸对大鼠心肌缺血再灌注损伤具有保护作用，可能与其提高血清和心肌组织中SOD活性、降低MDA和NO含量有关。
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| 关 键 词： | 牛磺酸 心肌缺血 再灌注 超氧化物歧化酶 丙二醛 一氧化氮 |
Protective effect of taurine on myocardial ischemia and reperfusion injury in rats |
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| YANG Jian,CAO Yong-An,JI Yue-E,SHI Wen-Yan.Protective effect of taurine on myocardial ischemia and reperfusion injury in rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2000,5(4):317-319. |
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| Authors: | YANG Jian CAO Yong-An JI Yue-E SHI Wen-Yan |
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| Abstract: | Aim To research the protective effect and mechanisms of taurine on myocardial ischemia and reperfusion injury in rats. Methods Myocardial ischemia reperfusion models were established in SD rats. The effects of taurine on the size of myocardial infarction and the changes of activity of SOD , and the levels of MDA and NO in myocardium and plasma of rats with myocardial ischemia and reperfusion injury were observed. Results In rats with myocardial ischemia and reperfusion injury, the taurine could reduce the size of myocardial infarction (P<0.05,0.01), raise the activity of SOD (P<0.01) and decrease the levels MDA and NO (P<0.05,0.01) in myocardium and plasma.Conclusion The taurine has protective effect on myocardial ischemia and reperfusion injury in rats. It may be related to raising the activity of SOD and decreasing the levels of MDA and NO in myocardiun and plasma. |
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| Keywords: | taurine myocardial ischemia and reperfusion superoxide dismutase(SOD) malondialdehyde(MDA) nitric oxide(NO) |
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