| 全反式维甲酸和阿糖胞苷对HL-60细胞端粒酶活性的影响 |
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| 引用本文： | 吴向华,叶开和,胡爱群. 全反式维甲酸和阿糖胞苷对HL-60细胞端粒酶活性的影响[J]. 中国临床药理学与治疗学, 2000, 5(1): 47-49 |
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| 作者姓名： | 吴向华 叶开和 胡爱群 |
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| 作者单位： | 1. 暨南大学医学院,广州,510630
2. 皖南医学院,芜湖,241001 |
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| 摘 要： | 目的 探讨全反式维甲酸（all trans-retinoic acid,ATRA)和阿糖胞苷（Ara-c)诱导人早幼粒细胞白血病细胞凋亡和分化的机制。方法 采用PCR－ELISA方法观察ATRA和Ara-c对HL－60细胞端粒酶活性的影响。结果 ATRA和Ara-c在诱导HL－60细胞凋亡和分化过程中均可使端粒酶 活性减低。结论 ATRA和Ara-c抑制HK－60细胞端粒酶的活性，可能是其诱导白血病细胞凋亡和分化的重要机制之一。
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| 关 键 词： | HL－60细胞 端粒酶 全反式维甲酸 阿糖胞苷 |
Effect of the all trans retinoic acid and Ara-c on the telomerase activity of HL-60 cells |
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| WU Xiang-Hua,YE Kai-He,HU Ai-Qun. Effect of the all trans retinoic acid and Ara-c on the telomerase activity of HL-60 cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2000, 5(1): 47-49 |
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| Authors: | WU Xiang-Hua YE Kai-He HU Ai-Qun |
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| Abstract: | Aim To investigate the possible mechanism of human promyelocytic leukemia cells differentiation and apoptosis induced by all trans_retinoic acid (ATRA) and Ara_c. Methods The effects of ATRA and Ara_c on the tolomerase activity of HL_60 cells were detected by PCR_ELISA. Results The tolomerase activity of HL_60 cells declined during the course of differentiation and apoptosis induced by ATRA and Ara_c. Conclusion These findings suggest that ATRA and Ara_c can inhibit tolomerase activity of HL_60 cells. It may be one of the important mechanisms of human promyelocytic leukemia cells differentiation and apoptosis induced by ATRA and Ara_c. |
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| Keywords: | HL_60 cell telomerase activity all trans_retinonic acid cytosire arabinoside |
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