右旋糖酐-40与呋噻米联合治疗新生儿硬肿症疗效探讨

目的：探讨静脉使用右旋糖酐-40与呋噻米联合治疗新生儿硬肿症的疗效。方法：将56例中、重度新生儿硬肿症患儿随机分为治疗组28例，对照组28例。两组均给予共同的综合性治疗措施，治疗组加用右旋糖酐-40，5-10ml／kg静脉滴注，呋噻米1mg/kg静脉推注，1次／d，疗程3—5d。观察两组皮肤硬肿消失时间、治愈率、病死率及不良反应。结果：治疗组皮肤硬肿消失时间早于对照组，差异有统计学意义（P〈0．001）；治疗组治愈率高于对照组，病死率低于对照组，差异均有统计学意义（P〈0．05），治疗过程中未发现药物不良反应。结论：静脉使用右旋糖酐40和呋噻米治疗新生儿硬肿症可缩短疗程，改善预后，使用安全，利于临床推广运用。

Combination of dextran-40 and furosemide for scleredema in newborn

Objective To investigate the effect of combination of intravenous dextran-40 and furosemide on scleredema in newborn.Method Total 56 newborns with moderate or severe scleredema were randomly divided into the treatment group(n=28) and the control group(n=28).Both groups were assigned to receive common comprehensive therapy,and the treatment group received add-on intravenous dextran-40(5～10ml/kg,once a day for 3～5days) followed by intravenous furosemide(1mg/kg,once a day for 3～5 days).Observation on the time when the hard skin swelling disappeared,the cure rates,mortalities and adverse reactions of both groups.Results Hard swollen skin in the treatment group disappeared earlier than the control group,the statistical difference was significant(P<0.001).The cure rate of the treatment group was significantly higher(P<0.05) and the mortality was lower(P<0.05) than those of the control group.And there were no adverse drug reactions found in the treatment group.Conclusion Combination of intravenous dextran-40 and furosemide for moderate or severe scleredema in newborn can shorten the treating course and improve the prognosis.This combination therapy is safe and can be used in clinic generally.