| 硫酸锌对大鼠移植胰腺再灌注损伤的保护作用 |
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| 引用本文： | 原春辉,修典荣,李丽君,宁力,袁国红,张同琳. 硫酸锌对大鼠移植胰腺再灌注损伤的保护作用[J]. 中国普通外科杂志, 2008, 17(11): 13-109 |
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| 作者姓名： | 原春辉 修典荣 李丽君 宁力 袁国红 张同琳 |
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| 作者单位： | (1.北京大学第三医院 普通外科，北京 100191; 2.中国医学科学院北京协和医院 基本外科，北京 100730) |
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| 基金项目： | 中国博士后科学基金(2003034029) |
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| 摘 要： | Objective:To study the protective effects of the heat shock protein 70 （HSP70）induced by zinc sulfate on reperfusion injury following pancreaticoduodenal transplantation in rats.Methods :The homologous male Wistar rat model of heterotopic total pancreaticoduodenal transplantation was used. The ZnSO4 treated rats received the intravenous injection of Zn2+5 mins before and after operation at a dose of 5 mg/kg (Zn 1 group),10 mg/kg(Zn 2 group) and 15 mg/kg(Zn 3 group), and the control group with the same volume of saline. The tissue concentration of HSP70 was determined using Western Blot. In addition，blood sugar (BG) and serum concentration of amylase and lipase were examined 24h after transplantation, and the activity of myeloperoxidase (MPO) in the pancrease graft was measured at the same time. Histological observation was performed.Results:Light microscopic studies showed that histomorphological changes of pancreas in Zn 2 group and Zn 1 group were much less than those in control group and Zn 3 group. The value of BG and serum lipase and MPO in Zn 2 group ＜ Zn 1 group
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| 关 键 词： | 胰腺／移植 再灌注 锌 热休克蛋白 |
| 收稿时间： | 1900-01-01 |
| 修稿时间： | 1900-01-01 |
Protective effects of zinc sulfate on the reperfusion injury following pancreaticoduodenal transplantation in rats |
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| YUAN Chunhui,XIU Dianrong,LI Lijun,NING Li,YUAN Guohong,ZHANG Tonglin. Protective effects of zinc sulfate on the reperfusion injury following pancreaticoduodenal transplantation in rats[J]. Chinese Journal of General Surgery, 2008, 17(11): 13-109 |
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| Authors: | YUAN Chunhui XIU Dianrong LI Lijun NING Li YUAN Guohong ZHANG Tonglin |
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| Affiliation: | YUAN Chunhui1,XIU Dianrong1,LI Lijun2,NING Li2,YUAN Guohong1,ZHANG Tonglin1(1.Department of General Surgery,the Third Hospital,Peking University,Beijing 100083,China,2.Department of Basic Surgery,Beijing Union Hospital,Chinese Academy of Medical Science,Beijing 100730,China) |
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| Abstract: | Objective To study the protective effects of the heat shock protein 70(HSP70)induced by zinc sulfate on reperfusion injury following pancreaticoduodenal transplantation in rats.Methods The homologous male Wistar rat model of heterotopic total pancreaticoduodenal transplantation was used.The ZnSO4 treated rats received the intravenous injection of Zn2+5 mins before and after operation at a dose of 5 mg/kg(Zn-1 group),10 mg/kg(Zn-2 group) and 15 mg/kg(Zn-3 group),and the control group with the same volume of ... |
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| Keywords: | Pancreas/transpl Reperfusion Zinc Heat Shock Protein |
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